March 2016

A man herding goats in an endemic focus of visceral leishmaniasis (Humera, Ethiopia). Sima et al.

Image Credit: Iva Rohousova

Editorials

The South China Sea and Its Neglected Tropical Diseases

Peter J. Hotez

PLOS Neglected Tropical Diseases: published March 31, 2016 | https://doi.org/10.1371/journal.pntd.0004395

The Zika Pandemic - A Perfect Storm?

Philip K. Russell

PLOS Neglected Tropical Diseases: published March 18, 2016 | https://doi.org/10.1371/journal.pntd.0004589

Viewpoints

Prospects for Moxidectin as a New Oral Treatment for Human Scabies

Kate E. Mounsey, Charlotte Bernigaud, Olivier Chosidow, James S. McCarthy

PLOS Neglected Tropical Diseases: published March 17, 2016 | https://doi.org/10.1371/journal.pntd.0004389

Funding and Innovation in Diseases of Neglected Populations: The Paradox of Cryptococcal Meningitis

Marcio L. Rodrigues

PLOS Neglected Tropical Diseases: published March 10, 2016 | https://doi.org/10.1371/journal.pntd.0004429

Symposiums

A 6-Year-Old Child with Severe Ebola Virus Disease: Laboratory-Guided Clinical Care in an Ebola Treatment Center in Guinea

Romain Palich, Jean-Luc Gala, Frédéric Petitjean, Susan Shepherd, Olivier Peyrouset, Bing M. Abdoul, Moumouni Kinda, Christine Danel, Augustin Augier, Xavier Anglaret, Denis Malvy, Nicole Blackwell, ALIMA N’zérékoré Ebola Treatment Center medical group

PLOS Neglected Tropical Diseases: published March 24, 2016 | https://doi.org/10.1371/journal.pntd.0004393

Coinfection of Leishmania (Viannia) braziliensis and Streptococcus pneumoniae in Multiple Cutaneous Lesions

Paulo R. Cortes, Laura S. Chiapello, David Dib, Monica V. Herrero, Carmen T. Nuncira, Carlos De Petris, Jose Echenique

PLOS Neglected Tropical Diseases: published March 10, 2016 | https://doi.org/10.1371/journal.pntd.0004388

Reviews

A Historical Overview of the Classification, Evolution, and Dispersion of Leishmania Parasites and Sandflies

Mohammad Akhoundi, Katrin Kuhls, Arnaud Cannet, Jan Votýpka, Pierre Marty, Pascal Delaunay, Denis Sereno

PLOS Neglected Tropical Diseases: published March 3, 2016 | https://doi.org/10.1371/journal.pntd.0004349

Eliminating the Neglected Tropical Diseases: Translational Science and New Technologies

Peter J. Hotez, Bernard Pecoul, Suman Rijal, Catharina Boehme, Serap Aksoy, Mwelecele Malecela, Roberto Tapia-Conyer, John C. Reeder

PLOS Neglected Tropical Diseases: published March 2, 2016 | https://doi.org/10.1371/journal.pntd.0003895

Zika Virus: Medical Countermeasure Development Challenges

Robert W. Malone, Jane Homan, Michael V. Callahan, Jill Glasspool-Malone, Lambodhar Damodaran, Adriano De Bernardi Schneider, Rebecca Zimler, James Talton, Ronald R. Cobb, Ivan Ruzic, Julie Smith-Gagen, Daniel Janies, James Wilson, Zika Response Working Group

PLOS Neglected Tropical Diseases: published March 2, 2016 | https://doi.org/10.1371/journal.pntd.0004530

Research Articles

Costs Associated with Malaria in Pregnancy in the Brazilian Amazon, a Low Endemic Area Where Plasmodium vivax Predominates

Camila Bôtto-Menezes, Azucena Bardají, Giselane dos Santos Campos, Silke Fernandes, Kara Hanson, Flor Ernestina Martínez-Espinosa, Clara Menéndez, Elisa Sicuri

PLOS Neglected Tropical Diseases: published March 31, 2016 | https://doi.org/10.1371/journal.pntd.0004494

Rift Valley Fever Vaccine Virus Clone 13 Is Able to Cross the Ovine Placental Barrier Associated with Foetal Infections, Malformations, and Stillbirths

Birgit Makoschey, Emma van Kilsdonk, Willem R. Hubers, Mieke P. Vrijenhoek, Marianne Smit, Paul J. Wichgers Schreur, Jeroen Kortekaas, Véronique Moulin

PLOS Neglected Tropical Diseases: published March 31, 2016 | https://doi.org/10.1371/journal.pntd.0004550

"Candidatus Borrelia kalaharica" Detected from a Febrile Traveller Returning to Germany from Vacation in Southern Africa

Volker Fingerle, Michael Pritsch, Martin Wächtler, Gabriele Margos, Sabine Ruske, Jette Jung, Thomas Löscher, Clemens Wendtner, Andreas Wieser

PLOS Neglected Tropical Diseases: published March 31, 2016 | https://doi.org/10.1371/journal.pntd.0004559

Comparison of Mucosal, Subcutaneous and Intraperitoneal Routes of Rat Leptospira Infection

Anne-Laure Zilber, Patrick Belli, Delphine Grezel, Marc Artois, Angeli Kodjo, Zoheira Djelouadji

PLOS Neglected Tropical Diseases: published March 31, 2016 | https://doi.org/10.1371/journal.pntd.0004569

Down-Regulation of TLR and JAK/STAT Pathway Genes Is Associated with Diffuse Cutaneous Leishmaniasis: A Gene Expression Analysis in NK Cells from Patients Infected with Leishmania mexicana

Edith A. Fernández-Figueroa, Iván Imaz-Rosshandler, Juan E. Castillo-Fernández, Haydee Miranda-Ortíz, Juan C. Fernández-López, Ingeborg Becker, Claudia Rangel-Escareño

PLOS Neglected Tropical Diseases: published March 31, 2016 | https://doi.org/10.1371/journal.pntd.0004570

Comparative Proteomics Identifies Host Immune System Proteins Affected by Infection with Mycobacterium bovis

Vladimir López, Margarita Villar, João Queirós, Joaquín Vicente, Lourdes Mateos-Hernández, Iratxe Díez-Delgado, Marinela Contreras, Paulo C. Alves, Pilar Alberdi, Christian Gortázar, José de la Fuente

PLOS Neglected Tropical Diseases: published March 30, 2016 | https://doi.org/10.1371/journal.pntd.0004541

Marking Triatoma brasiliensis, Triatoma pseudomaculata and Rhodnius nasutus Nymphs with Trace Elements: Element Persistence and Effects of Marking on Insect Mortality

Carolina Valença-Barbosa, Otília Sarquis, Aline Soares Freire, Mariana R. David, Ricardo E. Santelli, Fernando A. Monteiro, Marli M. Lima, Rafael Maciel-de-Freitas

PLOS Neglected Tropical Diseases: published March 30, 2016 | https://doi.org/10.1371/journal.pntd.0004548

Cost-Effectiveness of Antivenoms for Snakebite Envenoming in 16 Countries in West Africa

Muhammad Hamza, Maryam A. Idris, Musa B. Maiyaki, Mohammed Lamorde, Jean-Philippe Chippaux, David A. Warrell, Andreas Kuznik, Abdulrazaq G. Habib

PLOS Neglected Tropical Diseases: published March 30, 2016 | https://doi.org/10.1371/journal.pntd.0004568

Improved PCR-Based Detection of Soil Transmitted Helminth Infections Using a Next-Generation Sequencing Approach to Assay Design

Nils Pilotte, Marina Papaiakovou, Jessica R. Grant, Lou Ann Bierwert, Stacey Llewellyn, James S. McCarthy, Steven A. Williams

PLOS Neglected Tropical Diseases: published March 30, 2016 | https://doi.org/10.1371/journal.pntd.0004578

IL18 Gene Variants Influence the Susceptibility to Chagas Disease

Daniel A Leon Rodriguez, F. David Carmona, Luis Eduardo Echeverría, Clara Isabel González, Javier Martin

PLOS Neglected Tropical Diseases: published March 30, 2016 | https://doi.org/10.1371/journal.pntd.0004583

Assessing Lymphatic Filariasis Data Quality in Endemic Communities in Ghana, Using the Neglected Tropical Diseases Data Quality Assessment Tool for Preventive Chemotherapy

Dziedzom K. de Souza, Eric Yirenkyi, Joseph Otchere, Nana-Kwadwo Biritwum, Donne K. Ameme, Samuel Sackey, Collins Ahorlu, Michael D. Wilson

PLOS Neglected Tropical Diseases: published March 30, 2016 | https://doi.org/10.1371/journal.pntd.0004590

Allicin Induces Calcium and Mitochondrial Dysregulation Causing Necrotic Death in Leishmania

María J. Corral, Elena Benito-Peña, M. Dolores Jiménez-Antón, Laureano Cuevas, María C. Moreno-Bondi, José M. Alunda

PLOS Neglected Tropical Diseases: published March 29, 2016 | https://doi.org/10.1371/journal.pntd.0004525

Diagnostic Accuracy of Antigen 5-Based ELISAs for Human Cystic Echinococcosis

Daniela Pagnozzi, Maria Filippa Addis, Grazia Biosa, Anna Maria Roggio, Vittorio Tedde, Mara Mariconti, Francesca Tamarozzi, Valeria Meroni, Gabriella Masu, Giovanna Masala, Enrico Brunetti, Sergio Uzzau

PLOS Neglected Tropical Diseases: published March 29, 2016 | https://doi.org/10.1371/journal.pntd.0004585

Complexity of Infection and Genetic Diversity in Cambodian Plasmodium vivax

Lindsey R. Friedrich, Jean Popovici, Saorin Kim, Lek Dysoley, Peter A. Zimmerman, Didier Menard, David Serre

PLOS Neglected Tropical Diseases: published March 28, 2016 | https://doi.org/10.1371/journal.pntd.0004526

Prevalence and Genotype Allocation of Pathogenic Leptospira Species in Small Mammals from Various Habitat Types in Germany

Anna Obiegala, Dietlinde Woll, Carolin Karnath, Cornelia Silaghi, Susanne Schex, Sandra Eßbauer, Martin Pfeffer

PLOS Neglected Tropical Diseases: published March 25, 2016 | https://doi.org/10.1371/journal.pntd.0004501

Impact of Annual Praziquantel Treatment on Urogenital Schistosomiasis in a Seasonal Transmission Focus in Central Senegal

Bruno Senghor, Omar Talla Diaw, Souleymane Doucoure, Mouhamadane Seye, Adiouma Diallo, Idrissa Talla, Cheikh T. Bâ, Cheikh Sokhna

PLOS Neglected Tropical Diseases: published March 25, 2016 | https://doi.org/10.1371/journal.pntd.0004557

Antibody Profiling in Naïve and Semi-immune Individuals Experimentally Challenged with Plasmodium vivax Sporozoites

Myriam Arévalo-Herrera, Mary Lopez-Perez, Emmanuel Dotsey, Aarti Jain, Kelly Rubiano, Philip L. Felgner, D. Huw Davies, Sócrates Herrera

PLOS Neglected Tropical Diseases: published March 25, 2016 | https://doi.org/10.1371/journal.pntd.0004563

Coordinated Changes in Gene Expression Throughout Encystation of Giardia intestinalis

Elin Einarsson, Karin Troell, Marc P. Hoeppner, Manfred Grabherr, Ulf Ribacke, Staffan G. Svärd

PLOS Neglected Tropical Diseases: published March 25, 2016 | https://doi.org/10.1371/journal.pntd.0004571

Potential Harm of Prophylactic Platelet Transfusion in Adult Dengue Patients

Tau-Hong Lee, Joshua G. X. Wong, Yee-Sin Leo, Tun-Linn Thein, Ee-Ling Ng, Linda K. Lee, David C. Lye

PLOS Neglected Tropical Diseases: published March 25, 2016 | https://doi.org/10.1371/journal.pntd.0004576

Prevalence and Risk Factors of Hookworm-Related Cutaneous Larva Migrans (HrCLM) in a Resource-Poor Community in Manaus, Brazil

Felix Reichert, Daniel Pilger, Angela Schuster, Hannah Lesshafft, Silas Guedes de Oliveira, Ralf Ignatius, Hermann Feldmeier

PLOS Neglected Tropical Diseases: published March 24, 2016 | https://doi.org/10.1371/journal.pntd.0004514

Cyclical Patterns of Hand, Foot and Mouth Disease Caused by Enterovirus A71 in Malaysia

NMN NikNadia, I-Ching Sam, Sanjay Rampal, WMZ WanNorAmalina, Ghazali NurAtifah, Khebir Verasahib, Chia Ching Ong, MohdAidinniza MohdAdib, Yoke Fun Chan

PLOS Neglected Tropical Diseases: published March 24, 2016 | https://doi.org/10.1371/journal.pntd.0004562

Schistosomiasis Prevalence and Intensity of Infection in Latin America and the Caribbean Countries, 1942-2014: A Systematic Review in the Context of a Regional Elimination Goal

Ana Clara Zoni, Laura Catalá, Steven K. Ault

PLOS Neglected Tropical Diseases: published March 23, 2016 | https://doi.org/10.1371/journal.pntd.0004493

Sandfly-Borne Phlebovirus Isolations from Turkey: New Insight into the Sandfly fever Sicilian and Sandfly fever Naples Species

Cigdem Alkan, Ozge Erisoz Kasap, Bulent Alten, Xavier de Lamballerie, Rémi N. Charrel

PLOS Neglected Tropical Diseases: published March 23, 2016 | https://doi.org/10.1371/journal.pntd.0004519

Maternal Antibody-Mediated Disease Enhancement in Type I Interferon-Deficient Mice Leads to Lethal Disease Associated with Liver Damage

Julia María Martínez Gómez, Li Ching Ong, Jian Hang Lam, Siti Amanlina Binte Aman, Eshele Anak Libau, Pei Xuan Lee, Ashley L. St. John, Sylvie Alonso

PLOS Neglected Tropical Diseases: published March 23, 2016 | https://doi.org/10.1371/journal.pntd.0004536

Distribution of Pyrethroid Resistant Populations of Triatoma infestans in the Southern Cone of South America

Marinely Bustamante Gomez, Liléia Gonçalves Diotaiuti, David E. Gorla

PLOS Neglected Tropical Diseases: published March 23, 2016 | https://doi.org/10.1371/journal.pntd.0004561

Cost-Effectiveness of Blood Donation Screening for Trypanosoma cruzi in Mexico

Gilberto Sánchez-González, Alejandro Figueroa-Lara, Miguel Elizondo-Cano, Leslie Wilson, Barbara Novelo-Garza, Leopoldo Valiente-Banuet, Janine M. Ramsey

PLOS Neglected Tropical Diseases: published March 22, 2016 | https://doi.org/10.1371/journal.pntd.0004528

Willingness to Pay for Dog Rabies Vaccine and Registration in Ilocos Norte, Philippines (2012)

Meseret G. Birhane, Mary Elizabeth G. Miranda, Jessie L. Dyer, Jesse D. Blanton, Sergio Recuenco

PLOS Neglected Tropical Diseases: published March 21, 2016 | https://doi.org/10.1371/journal.pntd.0004486

Risk Factors for Bartonella species Infection in Blood Donors from Southeast Brazil

Pedro Paulo Vissotto de Paiva Diniz, Paulo Eduardo Neves Ferreira Velho, Luiza Helena Urso Pitassi, Marina Rovani Drummond, Bruno Grosselli Lania, Maria Lourdes Barjas-Castro, Stanley Sowy, Edward B. Breitschwerdt, Diana Gerardi Scorpio

PLOS Neglected Tropical Diseases: published March 21, 2016 | https://doi.org/10.1371/journal.pntd.0004509

Community Rates of IgG4 Antibodies to Ascaris Haemoglobin Reflect Changes in Community Egg Loads Following Mass Drug Administration

Johnny Vlaminck, Taniawati Supali, Peter Geldhof, Cornelis H. Hokke, Peter U. Fischer, Gary J. Weil

PLOS Neglected Tropical Diseases: published March 18, 2016 | https://doi.org/10.1371/journal.pntd.0004532

A Protein Complex Map of Trypanosoma brucei

Vahid H. Gazestani, Najmeh Nikpour, Vaibhav Mehta, Hamed S. Najafabadi, Houtan Moshiri, Armando Jardim, Reza Salavati

PLOS Neglected Tropical Diseases: published March 18, 2016 | https://doi.org/10.1371/journal.pntd.0004533

Transforming Clinical Data into Actionable Prognosis Models: Machine-Learning Framework and Field-Deployable App to Predict Outcome of Ebola Patients

Andres Colubri, Tom Silver, Terrence Fradet, Kalliroi Retzepi, Ben Fry, Pardis Sabeti

PLOS Neglected Tropical Diseases: published March 18, 2016 | https://doi.org/10.1371/journal.pntd.0004549

Pre-cut Filter Paper for Detecting Anti-Japanese Encephalitis Virus IgM from Dried Cerebrospinal Fluid Spots

Tehmina Bharucha, Anisone Chanthongthip, Soumphou Phuangpanom, Ooyanong Phonemixay, Onanong Sengvilaipaseuth, Manivanh Vongsouvath, Sue Lee, Paul N. Newton, Audrey Dubot-Pérès

PLOS Neglected Tropical Diseases: published March 17, 2016 | https://doi.org/10.1371/journal.pntd.0004516

Co-infection of Ticks: The Rule Rather Than the Exception

Sara Moutailler, Claire Valiente Moro, Elise Vaumourin, Lorraine Michelet, Florence Hélène Tran, Elodie Devillers, Jean-François Cosson, Patrick Gasqui, Van Tran Van, Patrick Mavingui, Gwenaël Vourc’h, Muriel Vayssier-Taussat

PLOS Neglected Tropical Diseases: published March 17, 2016 | https://doi.org/10.1371/journal.pntd.0004539

Is Dengue Vector Control Deficient in Effectiveness or Evidence?: Systematic Review and Meta-analysis

Leigh R. Bowman, Sarah Donegan, Philip J. McCall

PLOS Neglected Tropical Diseases: published March 17, 2016 | https://doi.org/10.1371/journal.pntd.0004551

Recombinant Salivary Proteins of Phlebotomus orientalis are Suitable Antigens to Measure Exposure of Domestic Animals to Sand Fly Bites

Michal Sima, Blanka Ferencova, Alon Warburg, Iva Rohousova, Petr Volf

PLOS Neglected Tropical Diseases: published March 17, 2016 | https://doi.org/10.1371/journal.pntd.0004553

Immune Response to Dengue Virus Infection in Pediatric Patients in New Delhi, India—Association of Viremia, Inflammatory Mediators and Monocytes with Disease Severity

Mohit Singla, Meenakshi Kar, Tavpritesh Sethi, Sushil K. Kabra, Rakesh Lodha, Anmol Chandele, Guruprasad R. Medigeshi

PLOS Neglected Tropical Diseases: published March 16, 2016 | https://doi.org/10.1371/journal.pntd.0004497

Evolutionary Analysis of Dengue Serotype 2 Viruses Using Phylogenetic and Bayesian Methods from New Delhi, India

Nazia Afreen, Irshad H. Naqvi, Shobha Broor, Anwar Ahmed, Syed Naqui Kazim, Ravins Dohare, Manoj Kumar, Shama Parveen

PLOS Neglected Tropical Diseases: published March 15, 2016 | https://doi.org/10.1371/journal.pntd.0004511

Factors Contributing to the Delay in Diagnosis and Continued Transmission of Leprosy in Brazil – An Explorative, Quantitative, Questionnaire Based Study

Mary Henry, Noêmi GalAn, Katherine Teasdale, Renata Prado, Harpreet Amar, Marina S. Rays, Lesley Roberts, Pedro Siqueira, Gilles de Wildt, Marcos Virmond, Pranab K. Das

PLOS Neglected Tropical Diseases: published March 15, 2016 | https://doi.org/10.1371/journal.pntd.0004542

Prevalence and Risk Factors for Intestinal Protozoan Infections with Cryptosporidium, Giardia, Blastocystis and Dientamoeba among Schoolchildren in Tripoli, Lebanon

Marwan Osman, Dima El Safadi, Amandine Cian, Sadia Benamrouz, Céline Nourrisson, Philippe Poirier, Bruno Pereira, Romy Razakandrainibe, Anthony Pinon, Céline Lambert, Ivan Wawrzyniak, Fouad Dabboussi, Frederic Delbac, Loïc Favennec, Monzer Hamze, Eric Viscogliosi, Gabriela Certad

PLOS Neglected Tropical Diseases: published March 14, 2016 | https://doi.org/10.1371/journal.pntd.0004496

Experimental Persistent Infection of BALB/c Mice with Small-Colony Variants of Burkholderia pseudomallei Leads to Concurrent Upregulation of PD-1 on T Cells and Skewed Th1 and Th17 Responses

Jia-Xiang See, Chandramathi Samudi, Alireza Saeidi, Nivedita Menon, Leang-Chung Choh, Jamuna Vadivelu, Esaki M. Shankar

PLOS Neglected Tropical Diseases: published March 14, 2016 | https://doi.org/10.1371/journal.pntd.0004503

Evaluation of Parasiticide Treatment with Benznidazol in the Electrocardiographic, Clinical, and Serological Evolution of Chagas Disease

Abilio Augusto Fragata-Filho, Francisco Faustino França, Claudia da Silva Fragata, Angela Maria Lourenço, Cristiane Castro Faccini, Cristiane Aparecida de Jesus Costa

PLOS Neglected Tropical Diseases: published March 14, 2016 | https://doi.org/10.1371/journal.pntd.0004508

Iminosugars Inhibit Dengue Virus Production via Inhibition of ER Alpha-Glucosidases—Not Glycolipid Processing Enzymes

Andrew C. Sayce, Dominic S. Alonzi, Sarah S. Killingbeck, Beatrice E. Tyrrell, Michelle L. Hill, Alessandro T. Caputo, Ren Iwaki, Kyoko Kinami, Daisuke Ide, J. L. Kiappes, P. Robert Beatty, Atsushi Kato, Eva Harris, Raymond A. Dwek, Joanna L. Miller, Nicole Zitzmann

PLOS Neglected Tropical Diseases: published March 14, 2016 | https://doi.org/10.1371/journal.pntd.0004524

Factors Associated with Correct and Consistent Insecticide Treated Curtain Use in Iquitos, Peru

Valerie A. Paz-Soldan, Karin Bauer, Amy C. Morrison, Jhonny J. Cordova Lopez, Kiyohiko Izumi, Thomas W. Scott, John P. Elder, Neal Alexander, Eric S. Halsey, Philip J. McCall, Audrey Lenhart

PLOS Neglected Tropical Diseases: published March 11, 2016 | https://doi.org/10.1371/journal.pntd.0004409

Effect of Two or Six Doses 800 mg of Albendazole Every Two Months on Loa loa Microfilaraemia: A Double Blind, Randomized, Placebo-Controlled Trial

Joseph Kamgno, Patrick Nguipdop-Djomo, Raceline Gounoue, Mathurin Téjiokem, Annette C. Kuesel

PLOS Neglected Tropical Diseases: published March 11, 2016 | https://doi.org/10.1371/journal.pntd.0004492

Dengue in Java, Indonesia: Relevance of Mosquito Indices as Risk Predictors

Siwi P. M. Wijayanti, Sunaryo Sunaryo, Suprihatin Suprihatin, Melanie McFarlane, Stephanie M. Rainey, Isabelle Dietrich, Esther Schnettler, Roman Biek, Alain Kohl

PLOS Neglected Tropical Diseases: published March 11, 2016 | https://doi.org/10.1371/journal.pntd.0004500

Preparing for and Executing a Randomised Controlled Trial of Podoconiosis Treatment in Northern Ethiopia: The Utility of Rapid Ethical Assessment

Henok Negussie, Thomas Addissie, Adamu Addissie, Gail Davey

PLOS Neglected Tropical Diseases: published March 11, 2016 | https://doi.org/10.1371/journal.pntd.0004531

Screening of the Open Source Malaria Box Reveals an Early Lead Compound for the Treatment of Alveolar Echinococcosis

Britta Stadelmann, Reto Rufener, Denise Aeschbacher, Markus Spiliotis, Bruno Gottstein, Andrew Hemphill

PLOS Neglected Tropical Diseases: published March 11, 2016 | https://doi.org/10.1371/journal.pntd.0004535

A Mycobacterial Perspective on Tuberculosis in West Africa: Significant Geographical Variation of M. africanum and Other M. tuberculosis Complex Lineages

Florian Gehre, Samrat Kumar, Lindsay Kendall, Mebrat Ejo, Oumie Secka, Boatema Ofori-Anyinam, Emmanuel Abatih, Martin Antonio, Dirk Berkvens, Bouke C. de Jong

PLOS Neglected Tropical Diseases: published March 10, 2016 | https://doi.org/10.1371/journal.pntd.0004408

Successful Treatment of Human Visceral Leishmaniasis Restores Antigen-Specific IFN-γ, but not IL-10 Production

Emebet Adem, Fitsumbirhan Tajebe, Mulusew Getahun, Amare Kiflie, Ermias Diro, Asrat Hailu, Ziv Shkedy, Bewketu Mengesha, Tadele Mulaw, Saba Atnafu, Tekalign Deressa, Biniam Mathewos, Ebba Abate, Manuel Modolell, Markus Munder, Ingrid Müller, Yegnasew Takele, Pascale Kropf

PLOS Neglected Tropical Diseases: published March 10, 2016 | https://doi.org/10.1371/journal.pntd.0004468

Identification and Analysis of the Role of Superoxide Dismutases Isoforms in the Pathogenesis of Paracoccidioides spp.

Diana Tamayo, José F. Muñoz, Ángela Lopez, Martha Urán, Juan Herrera, Clayton L. Borges, Ángela Restrepo, Celia M. Soares, Carlos P. Taborda, Agostinho J. Almeida, Juan G. McEwen, Orville Hernández

PLOS Neglected Tropical Diseases: published March 10, 2016 | https://doi.org/10.1371/journal.pntd.0004481

Unbiased Characterization of Anopheles Mosquito Blood Meals by Targeted High-Throughput Sequencing

Kyle Logue, John Bosco Keven, Matthew V. Cannon, Lisa Reimer, Peter Siba, Edward D. Walker, Peter A. Zimmerman, David Serre

PLOS Neglected Tropical Diseases: published March 10, 2016 | https://doi.org/10.1371/journal.pntd.0004512

Successful Control of Ebola Virus Disease: Analysis of Service Based Data from Rural Sierra Leone

Kamalini Lokuge, Grazia Caleo, Jane Greig, Jennifer Duncombe, Nicholas McWilliam, James Squire, Manjo Lamin, Emily Veltus, Anja Wolz, Gary Kobinger, Marc-Antoine de la Vega, Osman Gbabai, Sao Nabieu, Mohammed Lamin, Ronald Kremer, Kostas Danis, Emily Banks, Kathryn Glass

PLOS Neglected Tropical Diseases: published March 9, 2016 | https://doi.org/10.1371/journal.pntd.0004498

Evaluation of PCR Approaches for Detection of Bartonella bacilliformis in Blood Samples

Cláudia Gomes, Sandra Martinez-Puchol, Maria J. Pons, Jorge Bazán, Carmen Tinco, Juana del Valle, Joaquim Ruiz

PLOS Neglected Tropical Diseases: published March 9, 2016 | https://doi.org/10.1371/journal.pntd.0004529

Determinants of Human African Trypanosomiasis Elimination via Paratransgenesis

Jennifer A. Gilbert, Jan Medlock, Jeffrey P. Townsend, Serap Aksoy, Martial Ndeffo Mbah, Alison P. Galvani

PLOS Neglected Tropical Diseases: published March 8, 2016 | https://doi.org/10.1371/journal.pntd.0004465

School Water, Sanitation, and Hygiene, Soil-Transmitted Helminths, and Schistosomes: National Mapping in Ethiopia

Jack E. T. Grimes, Gemechu Tadesse, Kalkidan Mekete, Yonas Wuletaw, Abeba Gebretsadik, Michael D. French, Wendy E. Harrison, Lesley J. Drake, Iain A. Gardiner, Elodie Yard, Michael R. Templeton

PLOS Neglected Tropical Diseases: published March 8, 2016 | https://doi.org/10.1371/journal.pntd.0004515

Exposure versus Susceptibility as Alternative Bases for New Approaches to Surveillance for Schistosoma japonicum in Low Transmission Environments

Shuo Wang, Robert C. Spear

PLOS Neglected Tropical Diseases: published March 4, 2016 | https://doi.org/10.1371/journal.pntd.0004425

IL-33-Dependent Endothelial Activation Contributes to Apoptosis and Renal Injury in Orientia tsutsugamushi-Infected Mice

Thomas R. Shelite, Yuejin Liang, Hui Wang, Nicole L. Mendell, Brandon J. Trent, Jiaren Sun, Bin Gong, Guang Xu, Haitao Hu, Donald H. Bouyer, Lynn Soong

PLOS Neglected Tropical Diseases: published March 4, 2016 | https://doi.org/10.1371/journal.pntd.0004467

Mixed Methods Survey of Zoonotic Disease Awareness and Practice among Animal and Human Healthcare Providers in Moshi, Tanzania

Helen L. Zhang, Kunda W. Mnzava, Sarah T. Mitchell, Matayo L. Melubo, Tito J. Kibona, Sarah Cleaveland, Rudovick R. Kazwala, John A. Crump, Joanne P. Sharp, Jo E. B. Halliday

PLOS Neglected Tropical Diseases: published March 4, 2016 | https://doi.org/10.1371/journal.pntd.0004476

Polymorphisms in Plasmodium vivax Circumsporozoite Protein (CSP) Influence Parasite Burden and Cytokine Balance in a Pre-Amazon Endemic Area from Brazil

Bruno de Paulo Ribeiro, Gustavo Capatti Cassiano, Rodrigo Medeiros de Souza, Dalila Nunes Cysne, Marcos Augusto Grigolin Grisotto, Ana Paula Silva de Azevedo dos Santos, Cláudio Romero Farias Marinho, Ricardo Luiz Dantas Machado, Flávia Raquel Fernandes Nascimento

PLOS Neglected Tropical Diseases: published March 4, 2016 | https://doi.org/10.1371/journal.pntd.0004479

Towards Improving Point-of-Care Diagnosis of Non-malaria Febrile Illness: A Metabolomics Approach

Saskia Decuypere, Jessica Maltha, Stijn Deborggraeve, Nicholas J. W. Rattray, Guiraud Issa, Kaboré Bérenger, Palpouguini Lompo, Marc C. Tahita, Thusitha Ruspasinghe, Malcolm McConville, Royston Goodacre, Halidou Tinto, Jan Jacobs, Jonathan R. Carapetis

PLOS Neglected Tropical Diseases: published March 4, 2016 | https://doi.org/10.1371/journal.pntd.0004480

Burkholderia pseudomallei Colony Morphotypes Show a Synchronized Metabolic Pattern after Acute Infection

Philipp Gierok, Christian Kohler, Ivo Steinmetz, Michael Lalk

PLOS Neglected Tropical Diseases: published March 4, 2016 | https://doi.org/10.1371/journal.pntd.0004483

Have You Heard of Schistosomiasis? Knowledge, Attitudes and Practices in Nampula Province, Mozambique

Christian Rassi, Dan Kajungu, Sandrine Martin, Jorge Arroz, Jamie Tallant, Celine Zegers de Beyl, Helen Counihan, James N. Newell, Anna Phillips, Jane Whitton, Artur Manuel Muloliwa, Kirstie Graham

PLOS Neglected Tropical Diseases: published March 4, 2016 | https://doi.org/10.1371/journal.pntd.0004504

Hemophagocytosis in Experimental Visceral Leishmaniasis by Leishmania donovani

Ayako Morimoto, Satoko Omachi, Yasutaka Osada, James K. Chambers, Kazuyuki Uchida, Chizu Sanjoba, Yoshitsugu Matsumoto, Yasuyuki Goto

PLOS Neglected Tropical Diseases: published March 4, 2016 | https://doi.org/10.1371/journal.pntd.0004505

A Four-Point Screening Method for Assessing Molecular Mechanism of Action (MMOA) Identifies Tideglusib as a Time-Dependent Inhibitor of Trypanosoma brucei GSK3β

Zachary T. Swinney, Brad A. Haubrich, Shuangluo Xia, Chakk Ramesha, Stephen R. Gomez, Paul Guyett, Kojo Mensa-Wilmot, David C. Swinney

PLOS Neglected Tropical Diseases: published March 4, 2016 | https://doi.org/10.1371/journal.pntd.0004506

Genetic Manipulation of Leishmania donovani to Explore the Involvement of Argininosuccinate Synthase in Oxidative Stress Management

Abul Hasan Sardar, Armando Jardim, Ayan Kumar Ghosh, Abhishek Mandal, Sushmita Das, Savita Saini, Kumar Abhishek, Ruby Singh, Sudha Verma, Ajay Kumar, Pradeep Das

PLOS Neglected Tropical Diseases: published March 3, 2016 | https://doi.org/10.1371/journal.pntd.0004308

Epidemiology of Leprosy in Spain: The Role of the International Migration

José M. Ramos, David Romero, Isabel Belinchón

PLOS Neglected Tropical Diseases: published March 3, 2016 | https://doi.org/10.1371/journal.pntd.0004321

Assessment of the Effectiveness of a Seasonal-Long Insecticide-Based Control Strategy against Aedes albopictus Nuisance in an Urban Area

Beniamino Caputo, Mattia Manica, Antonello D’Alessandro, Giordano Bottà, Federico Filipponi, Carmela Protano, Matteo Vitali, Roberto Rosà, Alessandra della Torre

PLOS Neglected Tropical Diseases: published March 3, 2016 | https://doi.org/10.1371/journal.pntd.0004463

Risk of Intestinal Parasitic Infections in People with Different Exposures to Wastewater and Fecal Sludge in Kampala, Uganda: A Cross-Sectional Study

Samuel Fuhrimann, Mirko S. Winkler, Narcis B. Kabatereine, Edridah M. Tukahebwa, Abdulla A. Halage, Elizeus Rutebemberwa, Kate Medlicott, Christian Schindler, Jürg Utzinger, Guéladio Cissé

PLOS Neglected Tropical Diseases: published March 3, 2016 | https://doi.org/10.1371/journal.pntd.0004469

A Heterologous Multiepitope DNA Prime/Recombinant Protein Boost Immunisation Strategy for the Development of an Antiserum against Micrurus corallinus (Coral Snake) Venom

Henrique Roman Ramos, Inácio de Loiola M. Junqueira-de-Azevedo, Juliana Branco Novo, Karen Castro, Clara Guerra Duarte, Ricardo A. Machado-de-Ávila, Carlos Chavez-Olortegui, Paulo Lee Ho

PLOS Neglected Tropical Diseases: published March 3, 2016 | https://doi.org/10.1371/journal.pntd.0004484

Treatment of Cutaneous Leishmaniasis Caused by Leishmania aethiopica: A Systematic Review

Johan van Griensven, Endalamaw Gadisa, Abraham Aseffa, Asrat Hailu, Abate Mulugeta Beshah, Ermias Diro

PLOS Neglected Tropical Diseases: published March 3, 2016 | https://doi.org/10.1371/journal.pntd.0004495

Longitudinal Analysis of Natural Killer Cells in Dengue Virus-Infected Patients in Comparison to Chikungunya and Chikungunya/Dengue Virus-Infected Patients

Caroline Petitdemange, Nadia Wauquier, Hervé Devilliers, Hans Yssel, Illich Mombo, Mélanie Caron, Dieudonné Nkoghé, Patrice Debré, Eric Leroy, Vincent Vieillard

PLOS Neglected Tropical Diseases: published March 3, 2016 | https://doi.org/10.1371/journal.pntd.0004499

Leprosy New Case Detection Trends and the Future Effect of Preventive Interventions in Pará State, Brazil: A Modelling Study

Haroldo José de Matos, David J. Blok, Sake J. de Vlas, Jan Hendrik Richardus

PLOS Neglected Tropical Diseases: published March 3, 2016 | https://doi.org/10.1371/journal.pntd.0004507

Differential Susceptibilities of Aedes aegypti and Aedes albopictus from the Americas to Zika Virus

Thais Chouin-Carneiro, Anubis Vega-Rua, Marie Vazeille, André Yebakima, Romain Girod, Daniella Goindin, Myrielle Dupont-Rouzeyrol, Ricardo Lourenço-de-Oliveira, Anna-Bella Failloux

PLOS Neglected Tropical Diseases: published March 3, 2016 | https://doi.org/10.1371/journal.pntd.0004543

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