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November 2014

This graffiti of the Aedes aegypti breeding cycle was painted by local volunteers in Acapulco, Mexico, as part of a community-based effort to decrease dengue transmission (Camino Verde). The cycle highlights the local names given to the mosquitoes at the various developmental stages, and suggests strategies to limit their reproduction. Dengue fever is a major concern for millions of people in tropical and subtropical regions of the world. See Shepard et al.

Image Credit: Eduardo A. Undurraga

Editorial

Global Christianity and the Control of Its Neglected Tropical Diseases

Peter J. Hotez

Viewpoints

Strengthening Neglected Tropical Disease Research through Enhancing Research-Site Capacity: An Evaluation of a Novel Web Application to Facilitate Research Collaborations

Tamzin Furtado, Samuel Franzen, Francois van Loggerenberg, Gwenaelle Carn, Shannon Grahek, Megan McBride, Maureen Power, Jennifer O'Reilly, Barbara Savarese, Margaret Ann Snowden, Gwynn Stevens, Almarie Uys, Trudie Lang

Reviews

The Global One Health Paradigm: Challenges and Opportunities for Tackling Infectious Diseases at the Human, Animal, and Environment Interface in Low-Resource Settings

Wondwossen A. Gebreyes, Jean Dupouy-Camet, Melanie J. Newport, Celso J. B. Oliveira, Larry S. Schlesinger, Yehia M. Saif, Samuel Kariuki, Linda J. Saif, William Saville, Thomas Wittum, Armando Hoet, Sylvain Quessy, Rudovick Kazwala, Berhe Tekola, Thomas Shryock, Michael Bisesi, Prapas Patchanee, Sumalee Boonmar, Lonnie J. King

Research Articles

Coincident Helminth Infection Modulates Systemic Inflammation and Immune Activation in Active Pulmonary Tuberculosis

Parakkal Jovvian George, Nathella Pavan Kumar, Rathinam Sridhar, Luke E. Hanna, Dina Nair, Vaithilingam V. Banurekha, Thomas B. Nutman, Subash Babu

The Cultural Validation of Two Scales to Assess Social Stigma in Leprosy

Ruth M. H. Peters, Dadun, Wim H. Van Brakel, Marjolein B. M. Zweekhorst, Rita Damayanti, Joske F. G. Bunders, Irwanto

Whole Genome Sequence of the Treponema pallidum subsp. endemicum Strain Bosnia A: The Genome Is Related to Yaws Treponemes but Contains Few Loci Similar to Syphilis Treponemes

Barbora Štaudová, Michal Strouhal, Marie Zobaníková, Darina Čejková, Lucinda L. Fulton, Lei Chen, Lorenzo Giacani, Arturo Centurion-Lara, Sylvia M. Bruisten, Erica Sodergren, George M. Weinstock, David Šmajs

Topography and Land Cover of Watersheds Predicts the Distribution of the Environmental Pathogen Mycobacterium ulcerans in Aquatic Insects

Kevin Carolan, Andres Garchitorena, Gabriel E. García-Peña, Aaron Morris, Jordi Landier, Arnaud Fontanet, Philippe Le Gall, Gaëtan Texier, Laurent Marsollier, Rodolphe E. Gozlan, Sara Eyangoh, Danny Lo Seen, Jean-Francois Guégan

Engineering Attenuated Virulence of a Theileria annulata–Infected Macrophage

Nadia Echebli, Moez Mhadhbi, Marie Chaussepied, Catherine Vayssettes, James P. Di Santo, Mohamed Aziz Darghouth, Gordon Langsley

Achieving Population-Level Immunity to Rabies in Free-Roaming Dogs in Africa and Asia

Michelle K. Morters, Trevelyan J. McKinley, Daniel L. Horton, Sarah Cleaveland, Johan P. Schoeman, Olivier Restif, Helen R. Whay, Amelia Goddard, Anthony R. Fooks, I. Made Damriyasa, James L. N. Wood

Matrix Metalloproteinase 9 Production by Monocytes is Enhanced by TNF and Participates in the Pathology of Human Cutaneous Leishmaniasis

Taís M. Campos, Sara T. Passos, Fernanda O. Novais, Daniel P. Beiting, Rúbia S. Costa, Adriano Queiroz, David Mosser, Phillip Scott, Edgar M. Carvalho, Lucas P. Carvalho

Seroprevalence and Spatial Epidemiology of Lymphatic Filariasis in American Samoa after Successful Mass Drug Administration

Colleen L. Lau, Kimberly Y. Won, Luke Becker, Ricardo J. Soares Magalhaes, Saipale Fuimaono, Wayne Melrose, Patrick J. Lammie, Patricia M. Graves

Urbanization Increases Aedes albopictus Larval Habitats and Accelerates Mosquito Development and Survivorship

Yiji Li, Fatmata Kamara, Guofa Zhou, Santhosh Puthiyakunnon, Chunyuan Li, Yanxia Liu, Yanhe Zhou, Lijie Yao, Guiyun Yan, Xiao-Guang Chen

Psychometric Properties of the Participation Scale among Former Buruli Ulcer Patients in Ghana and Benin

Janine de Zeeuw, Marlies Douwstra, Till F. Omansen, Ghislain E. Sopoh, Christian Johnson, Richard O. Phillips, Marike Alferink, Paul Saunderson, Tjip S. Van der Werf, Pieter U. Dijkstra, Ymkje Stienstra

TLR9 Activation Is Triggered by the Excess of Stimulatory versus Inhibitory Motifs Present in Trypanosomatidae DNA

Mélissa Erin Khan, Chloé Borde, Eduardo P.C. Rocha, Véronique Mériaux, Vincent Maréchal, Pedro Escoll, Sophie Goyard, Jean-Marc Cavaillon, Bénédicte Manoury, Noëlle Doyen

Association between Footwear Use and Neglected Tropical Diseases: A Systematic Review and Meta-Analysis

Sara Tomczyk, Kebede Deribe, Simon J. Brooker, Hannah Clark, Khizar Rafique, Stefanie Knopp, Jürg Utzinger, Gail Davey

Clinical Features and Patient Management of Lujo Hemorrhagic Fever

Nivesh H. Sewlall, Guy Richards, Adriano Duse, Robert Swanepoel, Janusz Paweska, Lucille Blumberg, Thu Ha Dinh, Daniel Bausch

A Comprehensive Assessment of Lymphatic Filariasis in Sri Lanka Six Years after Cessation of Mass Drug Administration

Ramakrishna U. Rao, Kumara C. Nagodavithana, Sandhya D. Samarasekera, Asha D. Wijegunawardana, Welmillage D. Y. Premakumara, Samudrika N. Perera, Sunil Settinayake, J. Phillip Miller, Gary J. Weil

Related Articles

Leishmania infantum Ecto-Nucleoside Triphosphate Diphosphohydrolase-2 is an Apyrase Involved in Macrophage Infection and Expressed in Infected Dogs

Raphael De Souza Vasconcellos, Christiane Mariotini-Moura, Rodrigo Saar Gomes, Tiago Donatelli Serafim, Rafaela de Cássia Firmino, Matheus Silva e Bastos, Felipe Freitas de Castro, Claudia Miranda de Oliveira, Lucas Borges-Pereira, Anna Cláudia Alves de Souza, Ronny Francisco de Souza, Gabriel Andres Tafur Gómez, Aimara da Costa Pinheiro, Talles Eduardo Ferreira Maciel, Abelardo Silva-Júnior, Gustavo Costa Bressan, Márcia Rogéria Almeida, Munira Muhammad Abdel Baqui, Luís Carlos Crocco Afonso, Juliana Lopes Rangel Fietto

Persisting Social Participation Restrictions among Former Buruli Ulcer Patients in Ghana and Benin

Janine de Zeeuw, Till F. Omansen, Marlies Douwstra, Yves T. Barogui, Chantal Agossadou, Ghislain E. Sopoh, Richard O. Phillips, Christian Johnson, K. Mohammed Abass, Paul Saunderson, Pieter U. Dijkstra, Tjip S. van der Werf, Ymkje Stientstra

Related Articles

CD8+ T cells Are Preferentially Activated during Primary Low Dose Leishmania major Infection but Are Completely Dispensable during Secondary Anti-Leishmania Immunity

Ifeoma B. Okwor, Ping Jia, Zhirong Mou, Chukwunonso Onyilagha, Jude E. Uzonna

Patients' Perceptions on the Performance of a Local Health System to Eliminate Leprosy, Paraná State, Brazil

Flávia Meneguetti Pieri, Michelle Mosna Touso, Ludmila Barbosa Bandeira Rodrigues, Mellina Yamamura, Ione Carvalho Pinto, Elma Mathias Dessunti, Juliane de Almeida Crispim, Antônio Carlos Vieira Ramos, Luiz Henrique Arroyo, Marcelino Santos Neto, Maria Concebida da Cunha Garcia, Marcela Paschoal Popolin, Tatiane Ramos dos Santos Silveira, Ricardo Alexandre Arcêncio

The Colposcopic Atlas of Schistosomiasis in the Lower Female Genital Tract Based on Studies in Malawi, Zimbabwe, Madagascar and South Africa

Hanne M. Norseth, Patricia D. Ndhlovu, Elisabeth Kleppa, Bodo S. Randrianasolo, Peter M. Jourdan, Borghild Roald, Sigve D. Holmen, Svein G. Gundersen, Jayanthilall Bagratee, Mathias Onsrud, Eyrun F. Kjetland

Risk Factors for Buruli Ulcer in Ghana—A Case Control Study in the Suhum-Kraboa-Coaltar and Akuapem South Districts of the Eastern Region

Ernest Kenu, Kofi Mensah Nyarko, Linda Seefeld, Vincent Ganu, Michael Käser, Margaret Lartey, Benedict Nii Laryea Calys-Tagoe, Kwodwo Koram, Richard Adanu, Oliver Razum, Edwin Afari, Fred N. Binka

Assessing Progress in Reducing the At-Risk Population after 13 Years of the Global Programme to Eliminate Lymphatic Filariasis

Pamela J. Hooper, Brian K. Chu, Alexei Mikhailov, Eric A. Ottesen, Mark Bradley

Differential Dermal Expression of CCL17 and CCL18 in Tuberculoid and Lepromatous Leprosy

William R. Berrington, Chhatra B. Kunwar, Kapil Neupane, Susan J. F. van den Eeden, James C. Vary Jr., Glenna J. Peterson, Richard D. Wells, Annemieke Geluk, Deanna A. Hagge, Thomas R. Hawn

Retrospective Study of the Epidemiology and Clinical Manifestations of Cryptococcus gattii Infections in Colombia from 1997–2011

Jairo Lizarazo, Patricia Escandón, Clara Inés Agudelo, Carolina Firacative, Wieland Meyer, Elizabeth Castañeda

Serological Evidence of Henipavirus Exposure in Cattle, Goats and Pigs in Bangladesh

Sukanta Chowdhury, Salah Uddin Khan, Gary Crameri, Jonathan H. Epstein, Christopher C. Broder, Ausraful Islam, Alison J. Peel, Jennifer Barr, Peter Daszak, Lin-Fa Wang, Stephen P. Luby

Approaches to Refining Estimates of Global Burden and Economics of Dengue

Donald S. Shepard, Eduardo A. Undurraga, Miguel Betancourt-Cravioto, María G. Guzmán, Scott B. Halstead, Eva Harris, Rose Nani Mudin, Kristy O. Murray, Roberto Tapia-Conyer, Duane J. Gubler

An Integrated In Vitro Imaging Platform for Characterizing Filarial Parasite Behavior within a Multicellular Microenvironment

Timothy Kassis, Henry M. Skelton, Iris M. Lu, Andrew R. Moorhead, J. Brandon Dixon

Kinetics of Leptospira interrogans Infection in Hamsters after Intradermal and Subcutaneous Challenge

Mariana L. Coutinho, James Matsunaga, Long-Chieh Wang, Alejandro de la Peña Moctezuma, Michael S. Lewis, Jane T. Babbitt, Jose Antonio G. Aleixo, David A. Haake

Trypanocide Treatment of Women Infected with Trypanosoma cruzi and Its Effect on Preventing Congenital Chagas

Diana L. Fabbro, Emmaria Danesi, Veronica Olivera, Maria Olenka Codebó, Susana Denner, Cecilia Heredia, Mirtha Streiger, Sergio Sosa-Estani

Antibody-Dependent Enhancement Infection Facilitates Dengue Virus-Regulated Signaling of IL-10 Production in Monocytes

Tsung-Ting Tsai, Yi-Jui Chuang, Yee-Shin Lin, Chih-Peng Chang, Shu-Wen Wan, Sheng-Hsiang Lin, Chia-Ling Chen, Chiou-Feng Lin

Seasonal Drivers of the Epidemiology of Arthropod-Borne Viruses in Australia

Jemma L. Geoghegan, Peter J. Walker, Jean-Bernard Duchemin, Isabelle Jeanne, Edward C. Holmes

Indoleamine 2,3-Dioxygenase Controls Fungal Loads and Immunity in Paracoccidioidomicosis but is More Important to Susceptible than Resistant Hosts

Eliseu F. Araújo, Flávio V. Loures, Silvia B. Bazan, Claudia Feriotti, Adriana Pina, Alessandra S. Schanoski, Tânia A. Costa, Vera L. G. Calich

Pregnancy Outcome in Relation to Treatment of Murine Typhus and Scrub Typhus Infection: A Fever Cohort and a Case Series Analysis

Rose McGready, John Antony Jude Prakash, Santosh Joseph Benjamin, Wanitda Watthanaworawit, Tippawan Anantatat, Ampai Tanganuchitcharnchai, Clare L. Ling, Saw Oo Tan, Elizabeth A. Ashley, Mupawjay Pimanpanarak, Stuart D. Blacksell, Nicholas P. Day, Pratap Singhasivanon, Nicholas J. White, François Nosten, Daniel H. Paris

Spatiotemporal Transmission Dynamics of Hemorrhagic Fever with Renal Syndrome in China, 2005–2012

Wen-Yi Zhang, Li-Ya Wang, Yun-Xi Liu, Wen-Wu Yin, Wen-Biao Hu, Ricardo J. Soares. Magalhaes, Fan Ding, Hai-Long Sun, Hang Zhou, Shen-Long Li, Ubydul Haque, Shi-Lu Tong, Gregory E. Glass, Peng Bi, Archie C. A. Clements, Qi-Yong Liu, Cheng-Yi Li

Related Articles

Effect of the Brazilian Conditional Cash Transfer and Primary Health Care Programs on the New Case Detection Rate of Leprosy

Joilda Silva Nery, Susan Martins Pereira, Davide Rasella, Maria Lúcia Fernandes Penna, Rosana Aquino, Laura Cunha Rodrigues, Mauricio Lima Barreto, Gerson Oliveira Penna

Dengue and Chikungunya Fever among Viral Diseases in Outpatient Febrile Children in Kilosa District Hospital, Tanzania

Beatrice Chipwaza, Joseph P. Mugasa, Majige Selemani, Mbaraka Amuri, Fausta Mosha, Steve D. Ngatunga, Paul S. Gwakisa

Household Transmission of Vibrio cholerae in Bangladesh

Jonathan D. Sugimoto, Amanda A. Koepke, Eben E. Kenah, M. Elizabeth Halloran, Fahima Chowdhury, Ashraful I. Khan, Regina C. LaRocque, Yang Yang, Edward T. Ryan, Firdausi Qadri, Stephen B. Calderwood, Jason B. Harris, Ira M. Longini Jr.

The Plasmodium vivax Merozoite Surface Protein 3β Sequence Reveals Contrasting Parasite Populations in Southern and Northwestern Thailand

Chaturong Putaporntip, Jun Miao, Napaporn Kuamsab, Jetsumon Sattabongkot, Jeeraphat Sirichaisinthop, Somchai Jongwutiwes, Liwang Cui

Global Metabolomic Profiling of Acute Myocarditis Caused by Trypanosoma cruzi Infection

Núria Gironès, Sofía Carbajosa, Néstor A. Guerrero, Cristina Poveda, Carlos Chillón-Marinas, Manuel Fresno

Pathophysiologic and Transcriptomic Analyses of Viscerotropic Yellow Fever in a Rhesus Macaque Model

Flora Engelmann, Laurence Josset, Thomas Girke, Byung Park, Alex Barron, Jesse Dewane, Erika Hammarlund, Anne Lewis, Michael K. Axthelm, Mark K. Slifka, Ilhem Messaoudi

Identification of Ser/Thr kinase and Forkhead Associated Domains in Mycobacterium ulcerans: Characterization of Novel Association between Protein Kinase Q and MupFHA

Gunjan Arora, Andaleeb Sajid, Anshika Singhal, Jayadev Joshi, Richa Virmani, Meetu Gupta, Nupur Verma, Abhijit Maji, Richa Misra, Grégory Baronian, Amit K. Pandey, Virginie Molle, Yogendra Singh