May 2014

A bobcat crossing the path of a remotely triggered field camera looks out over a coastal California marsh that connects to sea otter habitat. Environmental transmission of the globally distributed zoonotic parasite, Toxoplasma gondii, has caused severe illness in people and animals, including California sea otters. Wild and domestic felids shed hardy T. gondii oocysts, which can infect hosts in diverse terrestrial environments and be carried in freshwater runoff to aquatic systems. See VanWormer et al.

Image Credit: Elizabeth VanWormer, One Health Institute, School of Veterinary Medicine, University of California, Davis

Editorial

Ten Global “Hotspots” for the Neglected Tropical Diseases

Peter J. Hotez

PLOS Neglected Tropical Diseases: published May 29, 2014 | https://doi.org/10.1371/journal.pntd.0002496

Viewpoints

From Haiti to the Amazon: Public Health Issues Related to the Recent Immigration of Haitians to Brazil

Tom Rawlinson, André Machado Siqueira, Gilberto Fontes, Renata Paula Lima Beltrão, Wuelton Marcelo Monteiro, Marilaine Martins, Edson Fidelis Silva-Júnior, Maria Paula Gomes Mourão, Bernardino Albuquerque, Maria das Graças Costa Alecrim, Marcus Vinícius Guimarães Lacerda

PLOS Neglected Tropical Diseases: published May 8, 2014 | https://doi.org/10.1371/journal.pntd.0002685

The Gulf Coast: A New American Underbelly of Tropical Diseases and Poverty

Peter J. Hotez, Kristy O. Murray, Pierre Buekens

PLOS Neglected Tropical Diseases: published May 15, 2014 | https://doi.org/10.1371/journal.pntd.0002760

Policy Platform

Control of Neglected Tropical Diseases in Burundi: Partnerships, Achievements, Challenges, and Lessons Learned after Four Years of Programme Implementation

Onésime Ndayishimiye, Giuseppina Ortu, Ricardo J. Soares Magalhaes, Archie Clements, Johan Willems, Jane Whitton, Warren Lancaster, Adrian Hopkins, Alan Fenwick

PLOS Neglected Tropical Diseases: published May 1, 2014 | https://doi.org/10.1371/journal.pntd.0002684

Historical Profiles and Perspectives

Giardia and Vilém Dušan Lambl

Marie Lipoldová

PLOS Neglected Tropical Diseases: published May 8, 2014 | https://doi.org/10.1371/journal.pntd.0002686

Building Endogenous Capacity for the Management of Neglected Tropical Diseases in Africa: The Pioneering Role of ICIPE

Daniel K. Masiga, Lilian Igweta, Rajinder Saini, James P. Ochieng'-Odero, Christian Borgemeister

PLOS Neglected Tropical Diseases: published May 15, 2014 | https://doi.org/10.1371/journal.pntd.0002687

Sterile Insects to Enhance Agricultural Development: The Case of Sustainable Tsetse Eradication on Unguja Island, Zanzibar, Using an Area-Wide Integrated Pest Management Approach

Marc J. B. Vreysen, Khalfan Saleh, Furaha Mramba, Andrew Parker, Udo Feldmann, Victor A. Dyck, Atway Msangi, Jérémy Bouyer

PLOS Neglected Tropical Diseases: published May 29, 2014 | https://doi.org/10.1371/journal.pntd.0002857

From Innovation to Application

Kenya Trypanosomiasis Research Institute Cryobank for Human and Animal Trypanosome Isolates to Support Research: Opportunities and Challenges

Grace A. Murilla, Kariuki Ndung'u, John K. Thuita, Purity K. Gitonga, Daniel T. Kahiga, Joanna E. Auma, Johnson O. Ouma, Jane J. Rutto, Joseph M. Ndung'u

PLOS Neglected Tropical Diseases: published May 22, 2014 | https://doi.org/10.1371/journal.pntd.0002747

Parasite Load Decrease during Application of a Safe and Easily Applied Antileishmanial Aminoglycoside Cream

Afif Ben Salah, Amor Zaâtour, Nathalie Ben Messaoud, Abdelhamid Kidar, Philip L. Smith, Karen M. Kopydlowski, Mara Kreishman-Deitrick, Carl J. Nielsen, Anne Novitt-Moreno, Janet H. Ransom, Gloria Morizot, Max Grogl, Pierre A. Buffet

PLOS Neglected Tropical Diseases: published May 22, 2014 | https://doi.org/10.1371/journal.pntd.0002749

Symposium

Kala-azar in Pregnancy in Mymensingh, Bangladesh: A Social Autopsy

Kazi Mizanur Rahman, Anna Olsen, David Harley, Colin D. Butler, Dinesh Mondal, Stephen P. Luby, Adrian C. Sleigh

PLOS Neglected Tropical Diseases: published May 1, 2014 | https://doi.org/10.1371/journal.pntd.0002710

Research Articles

Evaluation of Antiviral Efficacy of Ribavirin, Arbidol, and T-705 (Favipiravir) in a Mouse Model for Crimean-Congo Hemorrhagic Fever

Lisa Oestereich, Toni Rieger, Melanie Neumann, Christian Bernreuther, Maria Lehmann, Susanne Krasemann, Stephanie Wurr, Petra Emmerich, Xavier de Lamballerie, Stephan Ölschläger, Stephan Günther

PLOS Neglected Tropical Diseases: published May 1, 2014 | https://doi.org/10.1371/journal.pntd.0002804

A New Mouse Model for Female Genital Schistosomiasis

Monica L. Richardson, Chi-Ling Fu, Luke F. Pennington, Jared D. Honeycutt, Justin L. Odegaard, Yi-Ju Hsieh, Olfat Hammam, Simon L. Conti, Michael H. Hsieh

PLOS Neglected Tropical Diseases: published May 1, 2014 | https://doi.org/10.1371/journal.pntd.0002825

Trends in the Epidemiology of Pandemic and Non-pandemic Strains of Vibrio parahaemolyticus Isolated from Diarrheal Patients in Kolkata, India

Gururaja P. Pazhani, Sushanta K. Bhowmik, Santanu Ghosh, Sucharita Guin, Sanjucta Dutta, Krishnan Rajendran, Dhira Rani Saha, Ranjan K. Nandy, Mihir K. Bhattacharya, Asish K. Mukhopadhyay, Thandavarayan Ramamurthy

PLOS Neglected Tropical Diseases: published May 1, 2014 | https://doi.org/10.1371/journal.pntd.0002815

Statistical Modeling Reveals the Effect of Absolute Humidity on Dengue in Singapore

Hai-Yan Xu, Xiuju Fu, Lionel Kim Hock Lee, Stefan Ma, Kee Tai Goh, Jiancheng Wong, Mohamed Salahuddin Habibullah, Gary Kee Khoon Lee, Tian Kuay Lim, Paul Anantharajah Tambyah, Chin Leong Lim, Lee Ching Ng

PLOS Neglected Tropical Diseases: published May 1, 2014 | https://doi.org/10.1371/journal.pntd.0002805

Species-Directed Therapy for Leishmaniasis in Returning Travellers: A Comprehensive Guide

Caspar J. Hodiamont, Piet A. Kager, Aldert Bart, Henry J. C. de Vries, Pieter P. A. M. van Thiel, Tjalling Leenstra, Peter J. de Vries, Michèle van Vugt, Martin P. Grobusch, Tom van Gool

PLOS Neglected Tropical Diseases: published May 1, 2014 | https://doi.org/10.1371/journal.pntd.0002832

Prevalence and Serological Diagnosis of Relapse in Paracoccidioidomycosis Patients

Tatiane Fernanda Sylvestre, Luciane Regina Franciscone Silva, Ricardo de Souza Cavalcante, Daniela Vanessa Moris, James Venturini, Adriana Pardini Vicentini, Lídia Raquel de Carvalho, Rinaldo Poncio Mendes

PLOS Neglected Tropical Diseases: published May 1, 2014 | https://doi.org/10.1371/journal.pntd.0002834

Trans-spliced Heat Shock Protein 90 Modulates Encystation in Giardia lamblia

Rishi Kumar Nageshan, Nainita Roy, Shatakshi Ranade, Utpal Tatu

PLOS Neglected Tropical Diseases: published May 1, 2014 | https://doi.org/10.1371/journal.pntd.0002829

Enhanced Passive Bat Rabies Surveillance in Indigenous Bat Species from Germany - A Retrospective Study

Juliane Schatz, Conrad Martin Freuling, Ernst Auer, Hooman Goharriz, Christine Harbusch, Nicholas Johnson, Ingrid Kaipf, Thomas Christoph Mettenleiter, Kristin Mühldorfer, Ralf-Udo Mühle, Bernd Ohlendorf, Bärbel Pott-Dörfer, Julia Prüger, Hanan Sheikh Ali, Dagmar Stiefel, Jens Teubner, Rainer Günter Ulrich, Gudrun Wibbelt, Thomas Müller

PLOS Neglected Tropical Diseases: published May 1, 2014 | https://doi.org/10.1371/journal.pntd.0002835

Immunogenicity of a Killed Bivalent (O1 and O139) Whole Cell Oral Cholera Vaccine, Shanchol, in Haiti

Richelle C. Charles, Isabelle J. Hilaire, Leslie M. Mayo-Smith, Jessica E. Teng, J. Gregory Jerome, Molly F. Franke, Amit Saha, Yanan Yu, Paul Kováč, Stephen B. Calderwood, Edward T. Ryan, Regina C. LaRocque, Charles P. Almazor, Firdausi Qadri, Louise C. Ivers, Jason B. Harris

PLOS Neglected Tropical Diseases: published May 1, 2014 | https://doi.org/10.1371/journal.pntd.0002828

Discovery and Confirmation of Ligand Binding Specificities of the Schistosoma japonicum Polarity Protein Scribble

Pengfei Cai, Yi Mu, Xianyu Piao, Nan Hou, Shuai Liu, Youhe Gao, Heng Wang, Qijun Chen

PLOS Neglected Tropical Diseases: published May 1, 2014 | https://doi.org/10.1371/journal.pntd.0002837

Reliability of Trachoma Clinical Grading—Assessing Grading of Marginal Cases

Salman A. Rahman, Sun N. Yu, Abdou Amza, Sintayehu Gebreselassie, Boubacar Kadri, Nassirou Baido, Nicole E. Stoller, Joseph P. Sheehan, Travis C. Porco, Bruce D. Gaynor, Jeremy D. Keenan, Thomas M. Lietman

PLOS Neglected Tropical Diseases: published May 1, 2014 | https://doi.org/10.1371/journal.pntd.0002840

A Genome-Wide Analysis of Genetic Diversity in Trypanosoma cruzi Intergenic Regions

Leonardo G. Panunzi, Fernán Agüero

PLOS Neglected Tropical Diseases: published May 1, 2014 | https://doi.org/10.1371/journal.pntd.0002839

Field-Evaluation of a New Lateral Flow Assay for Detection of Cellular and Humoral Immunity against Mycobacterium leprae

Kidist Bobosha, Elisa M. Tjon Kon Fat, Susan J. F. van den Eeden, Yonas Bekele, Jolien J. van der Ploeg-van Schip, Claudia J. de Dood, Karin Dijkman, Kees L. M. C. Franken, Louis Wilson, Abraham Aseffa, John S. Spencer, Tom H. M. Ottenhoff, Paul L. A. M. Corstjens, Annemieke Geluk

PLOS Neglected Tropical Diseases: published May 8, 2014 | https://doi.org/10.1371/journal.pntd.0002845

Fitness Impact and Stability of a Transgene Conferring Resistance to Dengue-2 Virus following Introgression into a Genetically Diverse Aedes aegypti Strain

Alexander W. E. Franz, Irma Sanchez-Vargas, Robyn R. Raban, William C. Black IV, Anthony A. James, Ken E. Olson

PLOS Neglected Tropical Diseases: published May 8, 2014 | https://doi.org/10.1371/journal.pntd.0002833

Epidemiologic Features and Environmental Risk Factors of Severe Fever with Thrombocytopenia Syndrome, Xinyang, China

Kun Liu, Ning Cui, Li-Qun Fang, Bing-Jun Wang, Qing-Bin Lu, Wei Peng, Hao Li, Li-Yuan Wang, Song Liang, Hong-Yu Wang, Yao-Yun Zhang, Lu Zhuang, Hong Yang, Gregory C. Gray, Sake J. de Vlas, Wei Liu, Wu-Chun Cao

PLOS Neglected Tropical Diseases: published May 8, 2014 | https://doi.org/10.1371/journal.pntd.0002820

Cytokine Responses to the Anti-schistosome Vaccine Candidate Antigen Glutathione-S-transferase Vary with Host Age and Are Boosted by Praziquantel Treatment

Claire D. Bourke, Norman Nausch, Nadine Rujeni, Laura J. Appleby, François Trottein, Nicholas Midzi, Takafira Mduluza, Francisca Mutapi

PLOS Neglected Tropical Diseases: published May 8, 2014 | https://doi.org/10.1371/journal.pntd.0002846

Antileishmanial Activity of the Estrogen Receptor Modulator Raloxifene

Juliana Q. Reimão, Danilo C. Miguel, Noemi N. Taniwaki, Cristiana T. Trinconi, Jenicer K. U. Yokoyama-Yasunaka, Silvia R. B. Uliana

PLOS Neglected Tropical Diseases: published May 8, 2014 | https://doi.org/10.1371/journal.pntd.0002842

Reduction Patterns of Acute Schistosomiasis in the People's Republic of China

Shi-Zhu Li, Hao Zheng, Eniola Michael Abe, Kun Yang, Robert Bergquist, Ying-Jun Qian, Li-Juan Zhang, Zhi-Min Xu, Jing Xu, Jia-Gang Guo, Ning Xiao, Xiao-Nong Zhou

PLOS Neglected Tropical Diseases: published May 8, 2014 | https://doi.org/10.1371/journal.pntd.0002849

Assessing the Relationship between Vector Indices and Dengue Transmission: A Systematic Review of the Evidence

Leigh R. Bowman, Silvia Runge-Ranzinger, P. J. McCall

PLOS Neglected Tropical Diseases: published May 8, 2014 | https://doi.org/10.1371/journal.pntd.0002848

In Vitro and In Vivo Trypanocidal Activity of H₂bdtc-Loaded Solid Lipid Nanoparticles

Zumira A. Carneiro, Pedro I. da S. Maia, Renata Sesti-Costa, Carla D. Lopes, Tatiana A. Pereira, Cristiane M. Milanezi, Marcelo A. Pereira. da Silva, Renata F. V. Lopez, João S. Silva, Victor M. Deflon

PLOS Neglected Tropical Diseases: published May 8, 2014 | https://doi.org/10.1371/journal.pntd.0002847

Modeling Disease Vector Occurrence When Detection Is Imperfect II: Drivers of Site-Occupancy by Synanthropic Triatoma brasiliensis in the Brazilian Northeast

Carolina Valença-Barbosa, Marli M. Lima, Otília Sarquis, Claudia M. Bezerra, Fernando Abad-Franch

PLOS Neglected Tropical Diseases: published May 8, 2014 | https://doi.org/10.1371/journal.pntd.0002861

Diagnostic Accuracy and Cost-Effectiveness of Alternative Methods for Detection of Soil-Transmitted Helminths in a Post-Treatment Setting in Western Kenya

Liya M. Assefa, Thomas Crellen, Stella Kepha, Jimmy H. Kihara, Sammy M. Njenga, Rachel L. Pullan, Simon J. Brooker

PLOS Neglected Tropical Diseases: published May 8, 2014 | https://doi.org/10.1371/journal.pntd.0002843

Transcriptional and Proteomic Responses to Carbon Starvation in Paracoccidioides

Patrícia de Sousa Lima, Luciana Casaletti, Alexandre Melo Bailão, Ana Tereza Ribeiro de Vasconcelos, Gabriel da Rocha Fernandes, Célia Maria de Almeida Soares

PLOS Neglected Tropical Diseases: published May 8, 2014 | https://doi.org/10.1371/journal.pntd.0002855

INsPECT, an Open-Source and Versatile Software for Automated Quantification of (Leishmania) Intracellular Parasites

Ehsan Yazdanparast, Antonio Dos Anjos, Deborah Garcia, Corinne Loeuillet, Hamid Reza Shahbazkia, Baptiste Vergnes

PLOS Neglected Tropical Diseases: published May 15, 2014 | https://doi.org/10.1371/journal.pntd.0002850

Rabies in Nonhuman Primates and Potential for Transmission to Humans: A Literature Review and Examination of Selected French National Data

Philippe Gautret, Jesse Blanton, Laurent Dacheux, Florence Ribadeau-Dumas, Philippe Brouqui, Philippe Parola, Douglas H. Esposito, Hervé Bourhy

PLOS Neglected Tropical Diseases: published May 15, 2014 | https://doi.org/10.1371/journal.pntd.0002863

Mycobacterium ulcerans Ecological Dynamics and Its Association with Freshwater Ecosystems and Aquatic Communities: Results from a 12-Month Environmental Survey in Cameroon

Andrés Garchitorena, Benjamin Roche, Roger Kamgang, Joachim Ossomba, Jérémie Babonneau, Jordi Landier, Arnaud Fontanet, Antoine Flahault, Sara Eyangoh, Jean-François Guégan, Laurent Marsollier

PLOS Neglected Tropical Diseases: published May 15, 2014 | https://doi.org/10.1371/journal.pntd.0002879

Spatial Distribution of the Risk of Dengue and the Entomological Indicators in Sumaré, State of São Paulo, Brazil

Gerson Laurindo Barbosa, Maria Rita Donalísio, Celso Stephan, Roberto Wagner Lourenço, Valmir Roberto Andrade, Marylene de Brito Arduino, Virgilia Luna Castor de Lima

PLOS Neglected Tropical Diseases: published May 15, 2014 | https://doi.org/10.1371/journal.pntd.0002873

Hemoglobin Uptake by Paracoccidioides spp. Is Receptor-Mediated

Elisa Flávia Luiz Cardoso Bailão, Juliana Alves Parente, Laurine Lacerda Pigosso, Kelly Pacheco de Castro, Fernanda Lopes Fonseca, Mirelle Garcia Silva-Bailão, Sônia Nair Báo, Alexandre Melo Bailão, Marcio L. Rodrigues, Orville Hernandez, Juan G. McEwen, Célia Maria de Almeida Soares

PLOS Neglected Tropical Diseases: published May 15, 2014 | https://doi.org/10.1371/journal.pntd.0002856

Impact of ASHA Training on Active Case Detection of Visceral Leishmaniasis in Bihar, India

Vidya Nand Ravi Das, Ravindra Nath Pandey, Krishna Pandey, Varsha Singh, Vijay Kumar, Greg Matlashewski, Pradeep Das

PLOS Neglected Tropical Diseases: published May 22, 2014 | https://doi.org/10.1371/journal.pntd.0002774

Epidemiology and Genetic Variability of HHV-8/KSHV in Pygmy and Bantu Populations in Cameroon

Edouard Betsem, Olivier Cassar, Philippe V. Afonso, Arnaud Fontanet, Alain Froment, Antoine Gessain

PLOS Neglected Tropical Diseases: published May 15, 2014 | https://doi.org/10.1371/journal.pntd.0002851

Projected Future Distributions of Vectors of Trypanosoma cruzi in North America under Climate Change Scenarios

Miroslava Garza, Teresa Patricia Feria Arroyo, Edgar A. Casillas, Victor Sanchez-Cordero, Chissa-Louise Rivaldi, Sahotra Sarkar

PLOS Neglected Tropical Diseases: published May 15, 2014 | https://doi.org/10.1371/journal.pntd.0002818

Bothrops jararaca Venom Metalloproteinases Are Essential for Coagulopathy and Increase Plasma Tissue Factor Levels during Envenomation

Karine M. Yamashita, André F. Alves, Katia C. Barbaro, Marcelo L. Santoro

PLOS Neglected Tropical Diseases: published May 15, 2014 | https://doi.org/10.1371/journal.pntd.0002814

Benznidazole Biotransformation and Multiple Targets in Trypanosoma cruzi Revealed by Metabolomics

Andrea Trochine, Darren J. Creek, Paula Faral-Tello, Michael P. Barrett, Carlos Robello

PLOS Neglected Tropical Diseases: published May 22, 2014 | https://doi.org/10.1371/journal.pntd.0002844

Scabies Mite Inactive Serine Proteases Are Potent Inhibitors of the Human Complement Lectin Pathway

Simone L. Reynolds, Robert N. Pike, Angela Mika, Anna M. Blom, Andreas Hofmann, Lakshmi C. Wijeyewickrema, Dave Kemp, Katja Fischer

PLOS Neglected Tropical Diseases: published May 22, 2014 | https://doi.org/10.1371/journal.pntd.0002872

Sarcocystis nesbitti Causes Acute, Relapsing Febrile Myositis with a High Attack Rate: Description of a Large Outbreak of Muscular Sarcocystosis in Pangkor Island, Malaysia, 2012

Claire M. Italiano, Kum Thong Wong, Sazaly AbuBakar, Yee Ling Lau, Norlisah Ramli, Sharifah Faridah Syed Omar, Maria Kahar Bador, Chong Tin Tan

PLOS Neglected Tropical Diseases: published May 22, 2014 | https://doi.org/10.1371/journal.pntd.0002876

Distantiae Transmission of Trypanosoma cruzi: A New Epidemiological Feature of Acute Chagas Disease in Brazil

Samanta Cristina das Chagas Xavier, André Luiz Rodrigues Roque, Daniele Bilac, Vitor Antônio Louzada de Araújo, Sócrates Fraga da Costa Neto, Elias Seixas Lorosa, Luiz Felipe Coutinho Ferreira da Silva, Ana Maria Jansen

PLOS Neglected Tropical Diseases: published May 22, 2014 | https://doi.org/10.1371/journal.pntd.0002878

Designing a Community Engagement Framework for a New Dengue Control Method: A Case Study from Central Vietnam

Darlene McNaughton, Thi Thu Huong Duong

PLOS Neglected Tropical Diseases: published May 22, 2014 | https://doi.org/10.1371/journal.pntd.0002794

Helminth Colonization Is Associated with Increased Diversity of the Gut Microbiota

Soo Ching Lee, Mei San Tang, Yvonne A. L. Lim, Seow Huey Choy, Zachary D. Kurtz, Laura M. Cox, Uma Mahesh Gundra, Ilseung Cho, Richard Bonneau, Martin J. Blaser, Kek Heng Chua, P'ng Loke

PLOS Neglected Tropical Diseases: published May 22, 2014 | https://doi.org/10.1371/journal.pntd.0002880

Community Knowledge and Attitudes and Health Workers' Practices regarding Non-malaria Febrile Illnesses in Eastern Tanzania

Beatrice Chipwaza, Joseph P. Mugasa, Iddy Mayumana, Mbaraka Amuri, Christina Makungu, Paul S. Gwakisa

PLOS Neglected Tropical Diseases: published May 22, 2014 | https://doi.org/10.1371/journal.pntd.0002896

Incidence of Human Taenia solium Larval Infections in an Ecuadorian Endemic Area: Implications for Disease Burden Assessment and Control

Marco Coral-Almeida, Richar Rodríguez-Hidalgo, Maritza Celi-Erazo, Héctor Hugo García, Silvia Rodríguez, Brecht Devleesschauwer, Washington Benítez-Ortiz, Pierre Dorny, Nicolas Praet

PLOS Neglected Tropical Diseases: published May 22, 2014 | https://doi.org/10.1371/journal.pntd.0002887

Community Knowledge, Health Beliefs, Practices and Experiences Related to Dengue Fever and Its Association with IgG Seropositivity

Li Ping Wong, Sazaly AbuBakar, Karuthan Chinna

PLOS Neglected Tropical Diseases: published May 22, 2014 | https://doi.org/10.1371/journal.pntd.0002789

Multiple Resistances and Complex Mechanisms of Anopheles sinensis Mosquito: A Major Obstacle to Mosquito-Borne Diseases Control and Elimination in China

Xuelian Chang, Daibin Zhong, Qiang Fang, Joshua Hartsel, Guofa Zhou, Linna Shi, Fujin Fang, Changliang Zhu, Guiyun Yan

PLOS Neglected Tropical Diseases: published May 22, 2014 | https://doi.org/10.1371/journal.pntd.0002889

Population Pharmacokinetic Study of Benznidazole in Pediatric Chagas Disease Suggests Efficacy despite Lower Plasma Concentrations than in Adults

Jaime Altcheh, Guillermo Moscatelli, Guido Mastrantonio, Samanta Moroni, Norberto Giglio, Maria Elena Marson, Griselda Ballering, Margarita Bisio, Gideon Koren, Facundo García-Bournissen

PLOS Neglected Tropical Diseases: published May 22, 2014 | https://doi.org/10.1371/journal.pntd.0002907

Domestic Animal Hosts Strongly Influence Human-Feeding Rates of the Chagas Disease Vector Triatoma infestans in Argentina

Ricardo E. Gürtler, María C. Cecere, Gonzalo M. Vázquez-Prokopec, Leonardo A. Ceballos, Juan M. Gurevitz, María del Pilar Fernández, Uriel Kitron, Joel E. Cohen

PLOS Neglected Tropical Diseases: published May 22, 2014 | https://doi.org/10.1371/journal.pntd.0002894

Miltefosine and Antimonial Drug Susceptibility of Leishmania Viannia Species and Populations in Regions of High Transmission in Colombia

Olga Lucía Fernández, Yira Diaz-Toro, Clemencia Ovalle, Liliana Valderrama, Sandra Muvdi, Isabel Rodríguez, María Adelaida Gomez, Nancy Gore Saravia

PLOS Neglected Tropical Diseases: published May 22, 2014 | https://doi.org/10.1371/journal.pntd.0002871

High Parasitological Failure Rate of Visceral Leishmaniasis to Sodium Stibogluconate among HIV Co-infected Adults in Ethiopia

Ermias Diro, Lutgarde Lynen, Rezika Mohammed, Marleen Boelaert, Asrat Hailu, Johan van Griensven

PLOS Neglected Tropical Diseases: published May 22, 2014 | https://doi.org/10.1371/journal.pntd.0002875

The Interface between Methyltransferase and Polymerase of NS5 Is Essential for Flavivirus Replication

Xiao-Dan Li, Chao Shan, Cheng-Lin Deng, Han-Qing Ye, Pei-Yong Shi, Zhi-Ming Yuan, Peng Gong, Bo Zhang

PLOS Neglected Tropical Diseases: published May 22, 2014 | https://doi.org/10.1371/journal.pntd.0002891

Late Onset of the Serological Response against the 18 kDa Small Heat Shock Protein of Mycobacterium ulcerans in Children

Katharina Röltgen, Martin W. Bratschi, Amanda Ross, Samuel Y. Aboagye, Kobina A. Ampah, Miriam Bolz, Arianna Andreoli, James Pritchard, Jacques C. Minyem, Djeunga Noumen, Eric Koka, Alphonse Um Boock, Dorothy Yeboah-Manu, Gerd Pluschke

PLOS Neglected Tropical Diseases: published May 22, 2014 | https://doi.org/10.1371/journal.pntd.0002904

Intra-Subtype Variation in Enteroadhesion Accounts for Differences in Epithelial Barrier Disruption and Is Associated with Metronidazole Resistance in Blastocystis Subtype-7

Zhaona Wu, Haris Mirza, Kevin Shyong Wei Tan

PLOS Neglected Tropical Diseases: published May 22, 2014 | https://doi.org/10.1371/journal.pntd.0002885

Development of Peptide-Based Lineage-Specific Serology for Chronic Chagas Disease: Geographical and Clinical Distribution of Epitope Recognition

Tapan Bhattacharyya, Andrew K. Falconar, Alejandro O. Luquetti, Jaime A. Costales, Mario J. Grijalva, Michael D. Lewis, Louisa A. Messenger, Trang T. Tran, Juan-David Ramirez, Felipe Guhl, Hernan J. Carrasco, Patricio Diosque, Lineth Garcia, Sergey V. Litvinov, Michael A. Miles

PLOS Neglected Tropical Diseases: published May 22, 2014 | https://doi.org/10.1371/journal.pntd.0002892

One Health: Past Successes and Future Challenges in Three African Contexts

Anna L. Okello, Kevin Bardosh, James Smith, Susan C. Welburn

PLOS Neglected Tropical Diseases: published May 22, 2014 | https://doi.org/10.1371/journal.pntd.0002884

Spatio-Temporal Factors Associated with Meningococcal Meningitis Annual Incidence at the Health Centre Level in Niger, 2004–2010

Juliette Paireau, Halima B. Maïnassara, Jean-François Jusot, Jean-Marc Collard, Issa Idi, Jean-Paul Moulia-Pelat, Judith E. Mueller, Arnaud Fontanet

PLOS Neglected Tropical Diseases: published May 22, 2014 | https://doi.org/10.1371/journal.pntd.0002899

Dual RNA-seq of Parasite and Host Reveals Gene Expression Dynamics during Filarial Worm–Mosquito Interactions

Young-Jun Choi, Matthew T. Aliota, George F. Mayhew, Sara M. Erickson, Bruce M. Christensen

PLOS Neglected Tropical Diseases: published May 22, 2014 | https://doi.org/10.1371/journal.pntd.0002905

Serological Responses and Biomarker Evaluation in Mice and Pigs Exposed to Tsetse Fly Bites

Guy Caljon, Reta Duguma, Reginald De Deken, Stijn Schauvliege, Frank Gasthuys, Luc Duchateau, Jan Van Den Abbeele

PLOS Neglected Tropical Diseases: published May 22, 2014 | https://doi.org/10.1371/journal.pntd.0002911

Bacteriophage-Fused Peptides for Serodiagnosis of Human Strongyloidiasis

Nágilla Daliane Feliciano, Vanessa da Silva Ribeiro, Fabiana de Almeida Araújo Santos, Patricia Tiemi Fujimura, Henrique Tomaz Gonzaga, Luiz Ricardo Goulart, Julia Maria Costa-Cruz

PLOS Neglected Tropical Diseases: published May 29, 2014 | https://doi.org/10.1371/journal.pntd.0002792

Exposure to Multiple Parasites Is Associated with the Prevalence of Active Convulsive Epilepsy in Sub-Saharan Africa

Gathoni Kamuyu, Christian Bottomley, James Mageto, Brett Lowe, Patricia P. Wilkins, John C. Noh, Thomas B. Nutman, Anthony K. Ngugi, Rachael Odhiambo, Ryan G. Wagner, Angelina Kakooza-Mwesige, Seth Owusu-Agyei, Kenneth Ae-Ngibise, Honorati Masanja, Faith H. A. Osier, Peter Odermatt, Charles R. Newton, on behalf of the Study of Epidemiology of Epilepsy in Demographic Sites (SEEDS) group

PLOS Neglected Tropical Diseases: published May 29, 2014 | https://doi.org/10.1371/journal.pntd.0002908

Prospective Study of Leptospirosis Transmission in an Urban Slum Community: Role of Poor Environment in Repeated Exposures to the Leptospira Agent

Ridalva D. M. Felzemburgh, Guilherme S. Ribeiro, Federico Costa, Renato B. Reis, José E. Hagan, Astrid X. T. O. Melendez, Deborah Fraga, Francisco S. Santana, Sharif Mohr, Balbino L. dos Santos, Adriano Q. Silva, Andréia C. Santos, Romy R. Ravines, Wagner S. Tassinari, Marília S. Carvalho, Mitermayer G. Reis, Albert I. Ko

PLOS Neglected Tropical Diseases: published May 29, 2014 | https://doi.org/10.1371/journal.pntd.0002927

Interruption of Infection Transmission in the Onchocerciasis Focus of Ecuador Leading to the Cessation of Ivermectin Distribution

Raquel Lovato, Angel Guevara, Ronald Guderian, Roberto Proaño, Thomas Unnasch, Hipatia Criollo, Hassan K. Hassan, Charles D. Mackenzie

PLOS Neglected Tropical Diseases: published May 22, 2014 | https://doi.org/10.1371/journal.pntd.0002821

Seroprevalence and Modifiable Risk Factors for Toxocara spp. in Brazilian Schoolchildren

Alex J. F. Cassenote, Alba R. de Abreu Lima, José M. Pinto Neto, Guita Rubinsky-Elefant

PLOS Neglected Tropical Diseases: published May 29, 2014 | https://doi.org/10.1371/journal.pntd.0002830

Using Molecular Epidemiology to Track Toxoplasma gondii from Terrestrial Carnivores to Marine Hosts: Implications for Public Health and Conservation

Elizabeth VanWormer, Melissa A. Miller, Patricia A. Conrad, Michael E. Grigg, Daniel Rejmanek, Tim E. Carpenter, Jonna A. K. Mazet

PLOS Neglected Tropical Diseases: published May 29, 2014 | https://doi.org/10.1371/journal.pntd.0002852

Scabies Mites Alter the Skin Microbiome and Promote Growth of Opportunistic Pathogens in a Porcine Model

Pearl M. Swe, Martha Zakrzewski, Andrew Kelly, Lutz Krause, Katja Fischer

PLOS Neglected Tropical Diseases: published May 29, 2014 | https://doi.org/10.1371/journal.pntd.0002897

A Dual Drug Sensitive L. major Induces Protection without Lesion in C57BL/6 Mice

Noushin Davoudi, Ali Khamesipour, Fereidoun Mahboudi, W. Robert McMaster

PLOS Neglected Tropical Diseases: published May 29, 2014 | https://doi.org/10.1371/journal.pntd.0002785

Exploring the Potential of Flubendazole in Filariasis Control: Evaluation of the Systemic Exposure for Different Pharmaceutical Preparations

Laura Ceballos, Charles Mackenzie, Timothy Geary, Luis Alvarez, Carlos Lanusse

PLOS Neglected Tropical Diseases: published May 29, 2014 | https://doi.org/10.1371/journal.pntd.0002838

Safety and Efficacy Assessment of Two New Leprosy Skin Test Antigens: Randomized Double Blind Clinical Study

Becky L. Rivoire, Nathan A. Groathouse, Stephen TerLouw, Kapil Dev Neupane, Chaman Ranjit, Bishwa Raj Sapkota, Saraswoti Khadge, Chatra B. Kunwar, Murdo Macdonald, Rachel Hawksworth, Min B. Thapa, Deanna A. Hagge, Melinda Tibbals, Carol Smith, Tina Dube, Dewei She, Mark Wolff, Eric Zhou, Mamodikoe Makhene, Robin Mason, Christine Sizemore, Patrick J. Brennan

PLOS Neglected Tropical Diseases: published May 29, 2014 | https://doi.org/10.1371/journal.pntd.0002811

The Challenge of Producing Skin Test Antigens with Minimal Resources Suitable for Human Application against a Neglected Tropical Disease; Leprosy

Becky L. Rivoire, Stephen TerLouw, Nathan A. Groathouse, Patrick J. Brennan

PLOS Neglected Tropical Diseases: published May 29, 2014 | https://doi.org/10.1371/journal.pntd.0002791

The Concentrations of Ambient Burkholderia Pseudomallei during Typhoon Season in Endemic Area of Melioidosis in Taiwan

Ya-Lei Chen, Yu-Chuan Yen, Chun-Yuh Yang, Min Sheng Lee, Chi-Kung Ho, Kristina D. Mena, Peng-Yau Wang, Pei-Shih Chen

PLOS Neglected Tropical Diseases: published May 29, 2014 | https://doi.org/10.1371/journal.pntd.0002877

A Novel Universal Neutralizing Monoclonal Antibody against Enterovirus 71 That Targets the Highly Conserved “Knob” Region of VP3 Protein

Tanja K. Kiener, Qiang Jia, Tao Meng, Vincent Tak Kwong Chow, Jimmy Kwang

PLOS Neglected Tropical Diseases: published May 29, 2014 | https://doi.org/10.1371/journal.pntd.0002895

Corrections

Correction: Identification of Differentially Expressed Proteins from Leishmania amazonensis Associated with the Loss of Virulence of the Parasites

The PLOS Neglected Tropical Diseases Staff

PLOS Neglected Tropical Diseases: published May 22, 2014 | https://doi.org/10.1371/journal.pntd.0002956

Correction: A New Mouse Model for Female Genital Schistosomiasis

The PLOS Neglected Tropical Diseases Staff

PLOS Neglected Tropical Diseases: published May 22, 2014 | https://doi.org/10.1371/journal.pntd.0002957

Correction: Multilocus Sequence Analysis for Leishmania braziliensis Outbreak Investigation

The PLOS Neglected Tropical Diseases Staff

PLOS Neglected Tropical Diseases: published May 28, 2014 | https://doi.org/10.1371/journal.pntd.0002962

Correction: Development of Assays Using Hexokinase and Phosphoglucomutase Gene Sequences That Distinguish Strains of Leishmania tropica from Different Zymodemes and Microsatellite Clusters and Their Application to Palestinian Foci of Cutaneous Leishmaniasis

The PLOS Neglected Tropical Diseases Staff

PLOS Neglected Tropical Diseases: published May 28, 2014 | https://doi.org/10.1371/journal.pntd.0002963

Cover

Toxoplasma gondii: linking land and sea.

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From Innovation to Application

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