June 2008

Human monocyte-derived macrophages from a Leishmania-naïve donor were infected with Leishmania chagasi promastigote for 24 hrs, and co-cultured with purified CD3+ autologous T cells for an additional 24 hours. Cells were fixed and stained with Diff Quik. Images (600x) show an uninfected macrophage and several infected macrophages with intracellular amastigotes. Numerous T cells are visible in the image (see Ettinger and Wilson, doi:10.1371/journal.pntd.0000252).

Image Credit: Image generated by Nicholas A. Ettinger.

Viewpoints

Why Arboviruses Can Be Neglected Tropical Diseases

A. Desiree LaBeaud

PLOS Neglected Tropical Diseases: published June 25, 2008 | https://doi.org/10.1371/journal.pntd.0000247

Policy Platform

Trick or Treat: The Role of Vaccines in Integrated Schistosomiasis Control

Robert Bergquist, Jürg Utzinger, Donald P. McManus

PLOS Neglected Tropical Diseases: published June 25, 2008 | https://doi.org/10.1371/journal.pntd.0000244

Immunity against HIV/AIDS, Malaria, and Tuberculosis during Co-Infections with Neglected Infectious Diseases: Recommendations for the European Union Research Priorities

Diana Boraschi, Markos Abebe Alemayehu, Abraham Aseffa, Francesca Chiodi, John Chisi, Gianfranco Del Prete, T. Mark Doherty, Ibrahim Elhassan, Howard Engers, Ben Gyan, Ali M. Harandi, Thomas Kariuki, Fred Kironde, Bourema Kouriba, Jean Langhorne, Tamás Laskay, Donata Medaglini, Ole Olesen, Philip Onyebujoh, Carla Palma, Robert Sauerwein, Elopy Sibanda, Ulrich Steinhoff, Aldo Tagliabue, Andreas Thiel, Mahnaz Vahedi, Marita Troye-Blomberg

PLOS Neglected Tropical Diseases: published June 25, 2008 | https://doi.org/10.1371/journal.pntd.0000255

Review

Neglected Infections of Poverty in the United States of America

Peter J. Hotez

PLOS Neglected Tropical Diseases: published June 25, 2008 | https://doi.org/10.1371/journal.pntd.0000256

Research Articles

The Synergistic Effect of Concomitant Schistosomiasis, Hookworm, and Trichuris Infections on Children's Anemia Burden

Amara E. Ezeamama, Stephen T. McGarvey, Luz P. Acosta, Sally Zierler, Daria L. Manalo, Hai-Wei Wu, Jonathan D. Kurtis, Vincent Mor, Remigio M. Olveda, Jennifer F. Friedman

PLOS Neglected Tropical Diseases: published June 4, 2008 | https://doi.org/10.1371/journal.pntd.0000245

Genomic-Bioinformatic Analysis of Transcripts Enriched in the Third-Stage Larva of the Parasitic Nematode Ascaris suum

Cui-Qin Huang, Robin B. Gasser, Cinzia Cantacessi, Alasdair J. Nisbet, Weiwei Zhong, Paul W. Sternberg, Alex Loukas, Jason Mulvenna, Rui-Qing Lin, Ning Chen, Xing-Quan Zhu

PLOS Neglected Tropical Diseases: published June 18, 2008 | https://doi.org/10.1371/journal.pntd.0000246

A Genomic-Based Approach Combining In Vivo Selection in Mice to Identify a Novel Virulence Gene in Leishmania

Wen-Wei Zhang, Christopher S. Peacock, Greg Matlashewski

PLOS Neglected Tropical Diseases: published June 11, 2008 | https://doi.org/10.1371/journal.pntd.0000248

Tamoxifen Is Effective in the Treatment of Leishmania amazonensis Infections in Mice

Danilo C. Miguel, Jenicer K. U. Yokoyama-Yasunaka, Silvia R. B. Uliana

PLOS Neglected Tropical Diseases: published June 11, 2008 | https://doi.org/10.1371/journal.pntd.0000249

Bayesian Spatio-Temporal Modeling of Schistosoma japonicum Prevalence Data in the Absence of a Diagnostic ‘Gold’ Standard

Xian-Hong Wang, Xiao-Nong Zhou, Penelope Vounatsou, Zhao Chen, Jürg Utzinger, Kun Yang, Peter Steinmann, Xiao-Hua Wu

PLOS Neglected Tropical Diseases: published June 11, 2008 | https://doi.org/10.1371/journal.pntd.0000250

Cover

Leishmania chagasi-Infected Human Monocyte-Derived Macrophages Co-Cultured with Autologous Leishmania-Naïve T Cells