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Mouse Left Ear
Shown is cutaneous lesion development in a BALB/c mouse after inoculation of Leishmania braziliensis into the ear dermis. Previous research in mice has shown that immunity to sandfly saliva protects against the development of leishmaniasis. Researchers in Brazil observed that mice injected with sandfly saliva develop a specific response against salivary proteins; however, mice challenged with live Leishmania braziliensis in the presence of the saliva were not protected. Their findings could indicate possible hurdles in the development of leishmaniasis vaccines based on sandfly saliva (see de Moura et al., e84).
Image Credit: © 2007 Fabiano Oliveira
Editorial
Measuring Neglect
PLOS Neglected Tropical Diseases: published November 28, 2007 | https://doi.org/10.1371/journal.pntd.0000118
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Neglected Tropical Diseases, Neglected Data Sources, and Neglected Issues
PLOS Neglected Tropical Diseases: published November 7, 2007 | https://doi.org/10.1371/journal.pntd.0000104
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