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Deciphering of Chinese Bungarus multicinctus antivenin
Bungarus multicinctus is the most venomous snake distributed in China and neighboring countries. LD50 values of isolated α-, β- and γ-bungarotoxins determined via three administration pathways indicated that the toxicities of β-bungarotoxin were closely related with injection routines but those of both α- and γ-bungarotoxins were not related. Commercial B. multicinctus antivenin weakly recognized α- and γ-bungarotoxins. Although B. multicinctus antivenin showed immunoreaction with high molecular weight fractions of B. fasciatus, Naja atra, Ophiophagus hannah venoms, the antivenin only demonstrated animal protection efficacy against O. hannah venom. Lin, et al. (2020)
Image Credit: Dr. Wen-Hui Lee
Citation: (2021) PLoS Neglected Tropical Diseases Issue Image | Vol. 14(11) January 2021. PLoS Negl Trop Dis 14(11): ev14.i11. https://doi.org/10.1371/image.pntd.v14.i11
Published: January 15, 2021
Copyright: © 2021 . This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Bungarus multicinctus is the most venomous snake distributed in China and neighboring countries. LD50 values of isolated α-, β- and γ-bungarotoxins determined via three administration pathways indicated that the toxicities of β-bungarotoxin were closely related with injection routines but those of both α- and γ-bungarotoxins were not related. Commercial B. multicinctus antivenin weakly recognized α- and γ-bungarotoxins. Although B. multicinctus antivenin showed immunoreaction with high molecular weight fractions of B. fasciatus, Naja atra, Ophiophagus hannah venoms, the antivenin only demonstrated animal protection efficacy against O. hannah venom. Lin, et al. (2020)
Image Credit: Dr. Wen-Hui Lee