Figures
One drug to kill them many
We show that the essential protein translation machinery enzyme called lysyl tRNA synthetase (KRS) from different helminths can be inhibited by the same drug cladosporin. This active site binding inhibitor disables with equal potency both the African eye worm Loa loa's KRS and the snail fever causative agent S. mansoni's KRS. The structural and biochemical data suggest that derivatives of cladosporin may be promising new chemical series that can be rationally developed as new drugs against several neglected tropical diseases that are caused by eukaryotic parasites. Sharma et al.
Image Credit: J. Chhibber and Amit Sharma
Citation: (2016) PLoS Neglected Tropical Diseases Issue Image | Vol. 10(11) November 2016. PLoS Negl Trop Dis 10(11): ev10.i11. https://doi.org/10.1371/image.pntd.v10.i11
Published: November 30, 2016
Copyright: © 2016 Chhibber, Sharma. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
We show that the essential protein translation machinery enzyme called lysyl tRNA synthetase (KRS) from different helminths can be inhibited by the same drug cladosporin. This active site binding inhibitor disables with equal potency both the African eye worm Loa loa's KRS and the snail fever causative agent S. mansoni's KRS. The structural and biochemical data suggest that derivatives of cladosporin may be promising new chemical series that can be rationally developed as new drugs against several neglected tropical diseases that are caused by eukaryotic parasites. Sharma et al.
Image Credit: J. Chhibber and Amit Sharma