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Chikungunya virus-like particle vaccine
Chikungunya is an emerging mosquito-borne virus that causes arthritic disease in humans. Metz et al. describe a prototype chikungunya vaccine that is produced in insect cells using the baculovirus expression system. The vaccine consists of virus-like particles, which elicit a potent immune response and provide complete protection upon viral challenge against viremia and disease symptoms in mice. The picture shows a chikungunya virus-like particle visualized by transmission electron microscopy, merged with a chikungunya virion image (created with VMD, based on PDB ID:2XFB). This new effective and scalable vaccine candidate represents a step forward in the prevention of chikungunya virus infections.
Image Credit: Stefan W. Metz (Wageningen University, The Netherlands) and Jean-Yves Sgro (University of Wisconsin, Madison, United States)
Citation: (2013) PLoS Neglected Tropical Diseases Issue Image | Vol. 7(3) March 2013. PLoS Negl Trop Dis 7(3): ev07.i03. https://doi.org/10.1371/image.pntd.v07.i03
Published: March 28, 2013
Copyright: © 2013 Metz et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Chikungunya is an emerging mosquito-borne virus that causes arthritic disease in humans. Metz et al. describe a prototype chikungunya vaccine that is produced in insect cells using the baculovirus expression system. The vaccine consists of virus-like particles, which elicit a potent immune response and provide complete protection upon viral challenge against viremia and disease symptoms in mice. The picture shows a chikungunya virus-like particle visualized by transmission electron microscopy, merged with a chikungunya virion image (created with VMD, based on PDB ID:2XFB). This new effective and scalable vaccine candidate represents a step forward in the prevention of chikungunya virus infections.
Image Credit: Stefan W. Metz (Wageningen University, The Netherlands) and Jean-Yves Sgro (University of Wisconsin, Madison, United States)