Figures
Immunostaining for macrophage migration inhibitory factor in the lungs of mice.
Macrophage migration inhibitory factor (MIF) has emerged as a pivotal mediator of innate immunity and has been shown to be an important effector molecule in severe sepsis. Melioidosis, caused by Burkholderia pseudomallei, is an important cause of community-acquired sepsis in Southeast Asia. Here an immunostain for MIF is shown in the lungs of mice infected with B. pseudomallei. Positive immunostaining for MIF can be seen in the epithelial submucosa, bronchial epithelial cells, and inflammatory cells, most notably of alveolar macrophages (magnification x 10). MIF concentrations are markedly elevated during melioidosis and correlate with poor outcome. During experimental melioidosis MIF impairs antibacterial defense. (See article by Wiersinga et al., doi:10.1371/journal.pntd.0000605).
Image Credit: Sandrine Florquin (Department of Pathology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands).
Citation: (2010) PLoS Neglected Tropical Diseases Issue Image | Vol. 4(2) February 2010. PLoS Negl Trop Dis 4(2): ev04.i02. https://doi.org/10.1371/image.pntd.v04.i02
Published: February 23, 2010
Copyright: © 2010 Wiersinga et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Macrophage migration inhibitory factor (MIF) has emerged as a pivotal mediator of innate immunity and has been shown to be an important effector molecule in severe sepsis. Melioidosis, caused by Burkholderia pseudomallei, is an important cause of community-acquired sepsis in Southeast Asia. Here an immunostain for MIF is shown in the lungs of mice infected with B. pseudomallei. Positive immunostaining for MIF can be seen in the epithelial submucosa, bronchial epithelial cells, and inflammatory cells, most notably of alveolar macrophages (magnification x 10). MIF concentrations are markedly elevated during melioidosis and correlate with poor outcome. During experimental melioidosis MIF impairs antibacterial defense. (See article by Wiersinga et al., doi:10.1371/journal.pntd.0000605).
Image Credit: Sandrine Florquin (Department of Pathology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands).