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Fig 1.

Sampling locations for the clinical (blue pins) and tick-derived (green pins) samples.

Map image was generated using ArcGIS software [31,32,33].

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Table 1.

CT values and RNA copy numbers of CCHFV clinical and tick samples. *Samples collected from patients with reported contact to C18.

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Table 2.

Reference coverage and genotype of the analysed CCHFV samples. *Sample RNA enriched with SISPA followed by Illumina sequencing.

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Fig 2.

Maximum likelihood phylogeny for the S (A), M (B) and L (C) genomic segments.

Sequences have been colour-coded based on genotype affiliation of the S segment as follows: III (Africa-3, red), IV (Asia-1/IVa, blue; Asia-2/IVb, purple). Sequences generated in this study are indicated by black/white circles (clinical samples) or black rhombi (tick homogenate samples). White circles indicate sequences recovered from patients with reported contact. Sequences belonging to the identified Asia-1 S segment reassortant virus are indicated by red triangles. Genotype numbers are indicated next to the relevant clades. Except for single nodes which have been colour coded as described above, clades not relevant to this study have been compressed (black triangles).

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Fig 3.

Within group minimum and maximum pairwise identity (%) for both nucleotide (A) and amino acid (B) sequences for each CCHFV genomic segment.

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