Fig 1.
Map of French Guiana and gold mining area.
Part of the map was created using QGIS software. The background dataset are Natural Earth Data (https://www.naturalearthdata.com/downloads/10m-cultural-vectors/); the terms of use: http://www.naturalearthdata.com/about/terms-of-use/. The zoomed-in part is not licensed and is a reproduction of an article by Maylis Douine and al.[48] (Map back-ground from dmap: https://www.d-maps.com/carte.php?num_car=15480&lang=fr; the terms of use:https://www.d-maps.com/conditions.php?lang=fr).
Table 1.
Description of three confirmed cases rabies.
Fig 2.
Timeline of the clinical evolution of the three cases.
The date of collection of the different samples..
Fig 3.
Fluorescent antibody test and analysis of histologicsection of different brain areas collected from the three cases.
Fluorescent antibody test performed on brain areas of the three cases (A, B, D, F, G) and histological section of stained by Hematoxylin and Eosin “H&E” stain (C, E, H). Patient 1: A, cerebellum, magnification x40; B, cortex, magnification x40; C,cerebellum, magnification x150. Patient 2: D, hippocampus, magnification x40; cerebellum, resolution x100. Patient 3: F, hippocampus, magnification x40; G, brain stem, magnification x40; H, cerebellum, resolution x200. Black arrows show Negri bodies observed in rabies’s cases (intracytoplasmic eosinophilic, sharply outlined) pathognomonic inclusions in certain Purkinje neurons.
Fig 4.
Phylogenetic analysis of rabies virus.
Maximum likelihood phylogeny of rabies virus (RABV) from the Americas, highlighting host and geographic associations. The three sequences obtained from this study are located in the French Guyana cluster. The complete genome of the rabies virus was determined for Case 1 (independently from the cerebellum (sequence P1631) and from a non-specified area of the brain (Sequence P1632)) and Case 2 (from hippocampus, sequence P1642) (GenBank accession numbers PV606731, PV606730, PV606732, respectively). A color code indicates the species, order or family of the animal from which the virus was obtained.