Table 1.
Clinical profile of the patients at inclusion.
Fig 1.
Skin rash presentations of OROV and DENV infections in the assessed patients.
A) 27-year-old male with 6 days of symptoms diagnosed with OROV presented with rash on torso, upper and lower limbs. Patient also reported fever, arthralgia, myalgia, headache, retro-orbital pain, abdominal pain, vomiting, diarrhea, and dizziness. B) 32-year-old female with 6 days of symptoms diagnosed with OROV, presenting with rash on torso, upper and lower limbs. Patient had also reported fever, arthralgia, myalgia, severe headache, pruritus and had a positive tourniquet test. C) 43-year-old female with 3 days of symptoms diagnosed with DENV, presenting with rash on torso, upper and lower limbs. Patient had also reported fever, arthralgia, myalgia, pruritus, and mild headache. D) 26-year-old female, 8 weeks pregnant and with 3 days of symptoms diagnosed with DENV, presenting with rash on torso, upper and lower limbs with petechiae. Patient had also reported fever, myoarthralgia, mild headache, pruritus, and retro-orbital pain.
Fig 2.
Symptom burden and co-occurrence patterns in patients with Oropouche virus (OROV) and Dengue virus (DENV) infections.
A) Number of signs and symptoms in OROV patients, B) Number of signs and symptoms in DENV patients, C) and D) A network graph showing the co-occurrences of reported symptoms.
Table 2.
Clinical laboratory profile of the patients at inclusion.
Table 3.
Comparison of baseline symptoms in PCR- and PRNT-confirmed OROV cases.
Table 4.
Hematological and biochemical profile of OROV-positive patients by different diagnostic methods (PCR versus PRNT).
Fig 3.
Phylogenetic analysis of the OROV positive samples from Manaus, AM, Brazil, 2024.
Maximum likelihood phylogenetic tree of 64 representative OROV genomes, including twelve new genomes from this study. Phylogenetic trees are shown for the L segment (left), M segment (center), and S segment (right). The nodes are colored according to the location of each sample, specified in the legend. Phylogenies were midpoint rooted for clarity of presentation. Scale bar indicates the evolutionary distance of substitutions per nucleotide site. Bootstrap values based on 1,000 replicates are shown on principal nodes.
Fig 4.
Differential cytokine profile in the dengue virus infected patients at D1 and D28.
Fig 5.
Differential cytokine profile in the Oropouche virus infected patients at D1 and D28.