Table 1.
Age distribution of individuals from whom EPEC were recovered.
Table 2.
EPEC isolates isolated from recent southwest Nigeria epidemiological studies.
Table 3.
Identified EPEC from the studies.
Fig 1.
Maximum-likelihood whole-genome SNP-based tree of EPEC isolates from this study juxtaposed against source (location, age and health status of patient) and classification (typical/ atypical, classical or non-classical serovar, intimin type, phylogroup and ST) criteria.
Data are available in interactable format at https://microreact.org/project/hnPuLKV1d7pnskcG146MJj-epec-isolates-and-their-locations-2025.
Fig 2.
Maximum-likelihood whole-genome SNP-based tree and results of phylogenomic analysis of 61 EPEC isolates from Nigeria in this study and 67 international strains.
The inner ring represents the isolation sources and location, the middle ring represents the strain types, with the locally isolated strains in yellow, outer ring represent the phylogenomic lineages, ND; not determined Local isolates, NC; not classified international strains. Isolates from the Gambia that are closely related to isolates from primary health care centres in this study are marked with red crosses. Data are available in interactive format at: https://microreact.org/project/usSgwCwVrm1AZ76kHqfk1d-epec-local-and-international-strains.
Fig 3.
EPEC hybrids carrying pAA genes that define the EAEC pathotype (air, eilA, aggR, aap, aggA, agg4A, aar and capU) and/or ETEC (ltcA)-defining virulence genes.
Fig 4.
Characterization of a cluster of ST517 EPEC recovered in Ile-Ife. (a). Epicurve showing the dates of enrollment of children with diarrhea (top) and those from whom ST517 isolates were recovered (bottom). (b). Virulence and antimicrobial resistance genes in ST517 isolate from Ife that, based on sharing <10 SNPs, are believed to constitute an outbreak. (c). Age distribution of individuals from whom EPEC included in the tree in (b) were recovered with the red line representing the median age for each category. (d). The nutritional status of children from whom isolates in (b) above were collected.