Fig 1.
Flowchart of patient recruitment.
Table 1.
Baseline characteristics.
Fig 2.
Number of adverse events by treatment group.
The line inside each box is the median, the upper and lower margins of each box represent the interquartile range (25th – 75th percentile). Each dot represents the number of AEs of each individual patient, coloured by the treatment groups (cohort 1 contains the first 10 patients with a low dose of Metformin, cohort 2 contains the last 50 patients with a high dose of Metformin, and the control group). The numbers above the plots are the P values comparing each of the two groups (cohort 1 and cohort 2) with the control group using two-sample t-test. AE, adverse event.
Table 2.
Predefined adverse events for stopping metformin.
Table 3.
Clinical outcomes.
Table 4.
Frequency of warning signs and other symptoms during hospitalization.
Fig 3.
Kinetics of laboratory parameters.
Thick-coloured lines and coloured regions represent predicted values and 95% CIs from the linear mixed-effects models. Thick-coloured dots and whiskers represent predicted values and 95% CIs from the linear regression models at the follow-up period after day 18. Light-coloured lines represent the individual trajectory of the parameters. P values are derived from the linear mixed-effects model. P overall represents the overall effect of metformin, and P trend compares the trend over time between the two groups. ALT, alanine aminotransferase; AST, aspartate aminotransferase; CI, confidence interval; NS1, non-structural protein 1.