Fig 1.
The flowchart of recruiting and grouping patients.
Severe disease was defined as the presence of one or more of the following complications: encephalitis, hemorrhagic manifestations, or high viral load; mild disease was defined as the absence of these complications. Follow-up durations were categorized as follows: 6-month (within 6 months or between 6 and 8 months after disease onset), 12-month (between 8 and 12 months), 18-month (between 12 and 18 months), and 24-month (between 18 and 24 months). The LVL group referred to patients with a viral load ≤ 1 × 106 copies/mL on admission; the HVL group referred to patients with a viral load ≥ 1 × 106 copies/mL on admission. The medication and non-medication groups were defined based on whether patients received treatments such as favipiravir, ribavirin, and corticosteroids during the acute phase.
Table 1.
Summary of participant demographics and follow-up information.
Table 2.
Prevalence of clinical symptoms and laboratory findings on physical examination.
Fig 2.
The development of clinical sequelae in the SFTSV-LVL and HVL groups during the whole follow-up period.
The LVL group refered to patients with a viral load ≤ 1 × 106 copies/mL on admission; the HVL group refered to patients with a viral load ≥ 1 × 106 copies/mL on admission. The significant difference was obtained by using Chi-square test, with asterisks (*) denoting statistical significance. Symbols ‘↓’ and ‘↑’ denote lab values below and above normal, respectively.
Fig 3.
The odds ratios of sequelae between survivors and controls.
(A) The odds ratios of sequelae between survivors and controls in the 6-month group. The 6-month group refered to patients who were followed up within 6 months or between 6-8 months after the onset. (B) The odds ratios of sequelae between survivors and controls in the 12-month group. The 12-month group refered to patients who were followed up between 8 and 12 months after the onset. The dot indicates the odds ratio (OR), the line segment the confidence interval, and the vertical gray line an OR of 1. Calculated by logistic regression, ORs and P values adjusted for age, sex, delay from disease onset, underlying diseases, with P < 0.05 for significance. Symbols ‘↓’ and ‘↑’ denote lab values below and above normal, respectively. Abbreviations: ALT, alanine aminotransferase; AST, aspartate aminotransferase; BUN, blood urea nitrogen; CYSC, cystatin C; EOS%, eosinophil percentage; GGT, gamma-glutamyltransferase; LDH, lactate dehydrogenase; LYM%, lymphocyte percentage; MCH, mean corpuscular hemoglobin; MONO%, monocyte percentage; NEUT%, neutrophil percentage; PLT, platelet count; RDW, red cell distribution width-coefficient of variation; TBA, total bile acid; UA, uric acid; WBC, white blood cell count.