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Fig 1.

Flow chart of study selection for systematic review and meta-analysis of the effectiveness of carbon dioxide-based cryotherapy for the treatment cutaneous leishmaniasis, 2023.

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Fig 2.

Forest plot of the pooled effectiveness of carbon dioxide based cryotherapy for the treatment of cutaneous leishmaniasis, 2023.

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Fig 3.

Funnel plot showed the presence of publication bias estimating the effectiveness of cryotherapy among cutaneous leishmaniasis cases, 2023.

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Fig 4.

Sub-group analysis for the effectiveness of CO2 cryotherapy on the size of the lesion.

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Fig 5.

Sub-group analysis for the effectiveness of CO2 cryotherapy single application of treatment.

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Fig 6.

Sub-group analysis for the effectiveness of CO2 cryotherapy repeated application of treatment.

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Fig 7.

Galbraith plot showed the presence of outlier studies estimating the effectiveness of cryotherapy among cutaneous leishmaniasis cases, 2023.

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Fig 8.

Egger and Begg’s test showed the presence of publication bias estimating the effectiveness of cryotherapy among cutaneous leishmaniasis cases, 2023.

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Fig 9.

A table shows meta-regression outputs for the factors associated with the effectiveness of carbon dioxide cryotherapy for the treatment of localized cutaneous leishmaniasis, 2023.

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Fig 10.

Sensitivity analysis estimating the effectiveness of cryotherapy leishmaniasis cases, 2023.

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