Fig 1.
Initially, 484 patients diagnosed with SFTS were retrieved from the EMR system. A total of 433 SFTS patients were ultimately encompassed. 96 baseline-matched healthy individuals were included for comparison with SFTS patients. The SFTS patients were subsequently stratified into survival (n = 365) and death (n = 68) groups. After performing 3:1 matching, 204 data points from the survival group were retained.
Table 1.
Basic Characteristics of Healthy Controls vs. SFTS Patients.
Table 2.
Before and After Matching Results of SFTS Patients in Survival vs. Death Groups.
Fig 2.
Kaplan-Meier (KM) curves for SFTS patients with varied serum lipid profiles.
Survival analysis was conducted by dividing serum lipid profiles into two categories based on the median values. HR values and p values were calculated by using Cox proportional hazards regression. (a) KM curves for various serum lipid profiles in the pre-matched dataset. (b) KM curves for various serum lipid profiles in the post-matched dataset.
Table 3.
Cox Proportional Hazards Models of SFTS Patients in Survival vs. Death Groups.
Fig 3.
Longitudinal analysis of serum lipid profile trends over time.
(a) Serum lipid profile trends over time in the pre-matched dataset. (b) Serum lipid profile trends over time in the post-matched dataset. In the figure, the x-axis "days after onset of symptoms" indicates the number of days since the patient first reported the onset of symptoms. The dynamic changes in serum lipid profiles can reveal causal relationship between serum dyslipidemia and the mortality risk in SFTS. The specific values can be found in S5 Table.