Fig 1.
Flow diagram of participants with specific neurological signs/symptoms compatible with NCC (cohort 1).
TS POC: T. solium point-of-care test; rT24H-EITB: recombinant T24H enzyme-linked immunoelectrotransfer blot, serum Ag ELISA: enzyme-linked immunosorbent assay detecting Taenia antigens in serum; rES33-EITB: recombinant ES33 enzyme-linked immunoelectrotransfer blot, copro mPCR: multiplex polymerase chain reaction in stool, copro Ag ELISA: enzyme-linked immunosorbent assay detecting Taenia antigens in stool. The numbers after each of the taeniosis and cysticercosis test results refer to the number of positive samples.
Fig 2.
Flow diagram of participants with complaints compatible with intestinal worm infections (cohort 2).
TS POC: T. solium point-of-care test; rT24H-EITB: recombinant T24H enzyme-linked immunoelectrotransfer blot, serum Ag ELISA: enzyme-linked immunosorbent assay detecting Taenia antigens in serum; rES33-EITB: recombinant ES33 enzyme-linked immunoelectrotransfer blot, copro mPCR: multiplex polymerase chain reaction in stool, copro Ag ELISA: enzyme-linked immunosorbent assay detecting Taenia antigens in stool. The numbers after each of the taeniosis and cysticercosis test results refer to the number of positive samples.
Fig 3.
Flow diagram of participants attending district hospitals with symptoms other than neurological and gastro-intestinal (cohort 3).
TS POC: T. solium point-of-care test; rT24H-EITB: recombinant T24H enzyme-linked immunoelectrotransfer blot, serum Ag ELISA: enzyme-linked immunosorbent assay detecting Taenia antigens in serum; rES33-EITB: recombinant ES33 enzyme-linked immunoelectrotransfer blot, copro mPCR: multiplex polymerase chain reaction in stool, copro Ag ELISA: enzyme-linked immunosorbent assay detecting Taenia antigens in stool. The numbers after each of the taeniosis and cysticercosis test results refer to the number of positive samples.
Table 1.
Baseline characteristics of participants tested using the TS POC test, in each of the three cohorts, recruited in three district hospitals in Tanzania.
Table 2.
Cross tabulation of the tests used to detect taeniosis within the three cohorts (complete cases only, n = 287).
Fig 4.
Sensitivity and specificity of the TS POC T test strip, rES33-EITB, copro Ag ELISA and copro mPCR to detect taeniosis in three cohorts of participants recruited at district hospitals in Tanzania.
Results of the same cohort are indicated with the same colour. The error bars indicate the 95% credible intervals around the mean estimates. Cohort 1: participants with specific neurological signs and symptoms compatible with NCC (epilepsy and/or severe progressive headache); cohort 2: participants with complaints compatible with intestinal worm infections; cohort 3: participants with other symptom(s). TS POC T: T. solium point-of-care test strip for taeniosis; rES33-EITB: recombinant ES33 enzyme-linked immunoelectrotransfer blot, copro Ag ELISA: enzyme-linked immunosorbent assay detecting Taenia antigens in stool, copro mPCR: multiplex polymerase chain reaction in stool.
Table 3.
Agreement between the different tests for taenioisis and cysticercosis, for the three different cohorts of participants.
Table 4.
Cross tabulation of the tests used to detect cysticercosis within the three cohorts of participants (complete cases only; n = 303).
Fig 5.
Sensitivity and specificity of the TS POC CC test strip, rT24H-EITB and serum Ag ELISA to detect cysticercosis in three cohorts recruited in three district hospitals in Tanzania.
Results of the same cohort are indicated with the same color. The error bars indicate the 95% credible intervals around the mean estimates. Cohort 1: participants with specific neurological signs/symptoms compatible with NCC (epilepsy and/or severe progressive headache); cohort 2: participants with complaints compatible with intestinal worm infections; cohort 3: participants with other symptom(s). TS POC CC: T. solium point-of-care test for cysticercosis; rT24H-EITB: recombinant enzyme-linked immunoelectrotransfer blot; serum Ag ELISA: serum antigen enzyme-linked immunosorbent assay.