Table 1.
Baseline characteristics of participants by treatment arm.
Fig 1.
Compliance of study participants.
Data is presented as fraction of participants having provided a stool sample each day. 100% = 87 participants, average total: 52.4 (SD 11.6); Average IVM+ALB: 54.3 (SD 11.2); Average ALB: 50.6 (SD 14.1).
Fig 2.
T. trichiura egg excretion pattern with egg counts derived from Kato-Katz microscopy from participants in the albendazole-ivermectin treatment (A) and albendazole (B) group at logarithmic scale.
Points represent egg counts from a single sample, lines represent the daily mean eggs per gram (epg), violin plots show the distribution of epg per day. Red line: geometric mean. Blue line: arithmetic mean. Green line: median. BL = baseline, 1–28 = days post-treatment.
Fig 3.
Sensitivity and specificity analysis per day post-treatment for T. trichiura results derived from duplicate Kato-Katz slides.
Rates are calculated from the ratio of number of positive results vs number of true positives, as defined per the analysis.
Fig 4.
Daily pattern of T. trichiura copy numbers derived by qPCR from participants in the albendazole-ivermectin (A) albendazole monotherapy (B) treatment group at logarithmic scale.
Points represent copy numbers from a single sample, lines represent the daily mean copy numbers, violin plots show the distribution of copy numbers per day. Red line: geometric mean. Blue line: arithmetic mean. Green line: median. BL = baseline, 1–28 = days post-treatment.
Fig 5.
Sensitivity and specificity analysis per day post-treatment for T. trichiura results based on qPCR values.
Ground truth was defined using egg counts derived from duplicate Kato-Katz slides. Rates were calculated from the ratio of the number of samples positive by qPCR over the number of true positives.