Fig 1.
Flow diagram applied to select studies that involve the function of miRNAs with the development, monitoring, or prognosis of Chagas cardiomyopathy.
Fig 2.
miRNAs were included considering the contexts of the studies and type of samples used.
miRNAs were grouped into quadrants according to the context of the studies. The outer edge is color-coded to represent the sample type. The hearts in this figure have been modified from Servier Medical Art [28], licensed under a Creative Common Attribution 3.0 Generic License [29].
Table 1.
Review of subject, sample type, miRNA isolation, and miRNAs studied.
Fig 3.
Probable main mechanisms involved in the pathophysiology of ChCM.
RTKs: receptor tyrosine kinases; IFNGR1: interferon-gamma receptor 1; MAPK: mitogen-activated protein kinase; AKT: AKT serine/threonine kinase 1; STAT1: signal transducer and activator of transcription 1; NF-κB: nuclear factor kappa B; NOS2: nitric oxide synthase 2; ROS: reactive oxygen species; NO: nitric oxide; ONOO-: peroxynitrite; ΔΨm: mitochondrial membrane potential; mtDNA: mitochondrial DNA; OXPHOS: oxidative phosphorylation; CDND1: cyclin D1; TGFR: transforming growth factor beta receptor; SMAD2/3/5: SMAD family member 2, 3 and 5; SERCA2a: sarcoplasmic/endoplasmic reticulum Ca2+-ATPase; CACNA1C: calcium voltage-gated channel subunit alpha1 C; Ca2+: calcium ion; K+: potassium ion; KCNA1: potassium voltage-gated channel subfamily A member 1; GJA5: gap junction protein alpha 5. The hearts, receptors, ligands, ions channels, Trypanosoma, cell membrane, gap junctions, mitochondria, and lymphocyte cell in this figure have been modified from Servier Medical Art [28], licensed under a Creative Common Attribution 3.0 Generic License [29].
Fig 4.
miRNA-target interaction considering biological process and molecular function in the cardiac and immunological context.
The circular network shows miRNA and target interaction. Gene Ontology Biological Process (BM) and Molecular Function (MF) involved with the targets are color-coded at the top of the cycle. (GO: xxx = Gene Ontology entry number).