Fig 1.
Flowchart of selection of studies for inclusion in the meta-analysis.
Table 1.
Characteristics of the included studies in the TNF-α -308G >A polymorphism and its associations with severe P. falciparum malaria.
Table 2.
Details of genotype frequencies of the TNF-α -308G >A polymorphism in case and control.
Table 3.
Summary effects of the TNF-α -308G >A polymorphism with susceptibility to severe P. falciparum malaria.
Fig 2.
Forest plot subgroup analysis of association of TNF-α -308G >A polymorphism with severe P. falciparum malaria in dominant and codominant model.
(A) African dominant (B) Asian dominant (C) African codominant and (D) Asian codomiant. CI: confidence interval; TNF-α: tumor necrosis factor-alpha; CI: confidence interval; df: degree of freedom; I2: measure of variability; UM: uncomplicated malaria; SM: severe malaria.
Table 4.
Tests of interactions and sensitivity analysis.