Fig 1.
Schematic of maternal-to-infant transfer of drugs showing routinely estimated pharmacokinetic exposure factors and different factors that affect infant exposure (Clipart image obtained from https://openclipart.org/search/?query=breastfeeding+mother; date cited: May 30, 2023).
Table 1.
World Health Organization (WHO)-recommended drugs for the treatment of malaria, tuberculosis (including RR/MDR), and neglected tropical diseases (NTDs).
Fig 2.
Information sources and search strategies.
Fig 3.
Schematic workflow undertaken for extraction of information on lactation pharmacokinetics for drugs used to treat malaria, tuberculosis, and NTDs.
Table 2.
Key findings in studies evaluating mother-to-infant transfer of antimalarials, antituberculosis, and drugs for neglected tropical diseases (NTDs).
Fig 4.
Schematic depiction of the plasma and breast milk changes in drug concentrations across time comparing non-compartmental and compartmental analysis.
Left panel: Non-compartmental analysis; right panel: Compartmental analysis; open circles: Individual drug concentration data, plasma (black) and breast milk (blue); Lines: Individual drug concentration-time profiles in plasma (black) and breast milk (blue); solid lines: Population drug concentration-time profile in plasma (black) and breast milk (blue).