Fig 1.
Study selection flow diagram: A. For the WHO and CDC websites search; B. For the systematic literature search.
Table 1.
Characteristics of included studies.
Fig 2.
Worldwide distribution of VHF.
The color denotes the number of VHF with at least one outbreak reported by country and the acronyms denote the names of the VHFs. Note: AHF, Alkhurma hemorrhagic fever; ArHF, Argentine hemorrhagic fever; BHF, Bolivian hemorrhagic fever; CHF, Chapare hemorrhagic fever; CCHF, Crimean-Congo hemorrhagic fever; EVD, Ebola Virus Disease; HPS, Hantavirus Pulmonary Syndrome; HFRS, Hemorrhagic fever with renal syndrome; LF, Lassa fever; LHF, Lujo hemorrhagic fever; MVD, Marburg virus disease; OHF, Omsk hemorrhagic fever; RVF, Rift Valley fever; SHF, Sabia hemorrhagic fever; VeHF, Venezuelan hemorrhagic fever. Maps were generated with the ‘maps’ R package using data from the Natural Earth Project (the 1:50m resolution version).
Fig 3.
Distribution of number of cases and CFR of Crimean-Congo hemorrhagic fever.
The size of the bubble is proportional with the number of cases reported and the color denotes the level of CFR by country. Note: Maps were generated with the ‘maps’ R package using data from the Natural Earth Project (the 1:50m resolution version).
Fig 4.
Distribution of number of cases and CFR of Ebola Virus Disease.
The size of the bubble is proportional with the number of cases reported and the color denotes the level of CFR by country. Note: Maps were generated with the ‘maps’ R package using data from the Natural Earth Project (the 1:50m resolution version).
Fig 5.
Distribution of number of cases and CFR of Hantavirus Pulmonary Syndrome.
The size of the bubble is proportional with the number of cases reported and the color denotes the level of CFR by country. Note: Maps were generated with the ‘maps’ R package using data from the Natural Earth Project (the 1:50m resolution version).
Fig 6.
Distribution of number of cases and CFR of Lassa fever.
The size of the bubble is proportional with the number of cases reported and the color denotes the level of CFR by country. Note: Maps were generated with the ‘maps’ R package using data from the Natural Earth Project (the 1:50m resolution version).
Fig 7.
Distribution of number of cases and CFR of Rift Valley Fever.
The size of the bubble is proportional with the number of cases reported and the color denotes the level of CFR by country. Note: Maps were generated with the ‘maps’ R package using data from the Natural Earth Project (the 1:50m resolution version).
Table 2.
Characteristics of included studies reporting results on treatments by VHF.
Table 3.
Mortality results associated with VHFs treatments reported in the included studies.