Table 1.
Demographic data of study participants.
Fig 1.
Population predicted (PRED) vs Observed (DV) benznidazole concentrations (mg/L).
Fig 2.
Individual predicted (IPRED) vs Observed (DV) benznidazole concentrations (mg/L).
Fig 3.
Visual Predicted Check (VPC) plot, 1 compartment model with oral absorption, final model with covariates.
Table 2.
Final parameter estimates, with covariates.
Fig 4.
Clearance (CL/F) vs Age (years).
CL/F increases rapidly during the first year of life, and reaches the reported adult level approximately at 10 years of age (filled circles: individual estimates for CL/F; lines: median and CI5% and CI95% for CL/F).
Fig 5.
Weight-corrected CL/F, showing decrease with age (filled circles: individual estimates for weight-corrected CL/F; lines: median and CI5% and CI95% for CL/F).
Table 3.
Estimated Css* by relevant age group, assuming a BNZ dose of 7 mg/kg/day.