Table 1.
Summary of in-vitro data.
Table 2.
Percentage of time above the lower and upper range of the EC50/90 and above the EC50/90 means for the different ribavirin regiments based on PK modelling.
Fig 1.
Pharmacokinetic simulations of the different ribavirin regimens.
A) McCormick regimen day 0–10 and B) 0–72 hours. C) Irrua non-pregnant regimen day 0–10 and D) 0–72 hours. E) Irrua pregnant regimen day 0–10 and F) 0–72 hours. Dash lines represent mean EC50 and mean EC90.
Table 3.
Summary of animal data.