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Fig 1.

The affected areas (◼) within Bam county and peri-urban areas in Kerman city, southeastern Iran.

GIS layers prepared by the National Cartographic Center of Iran (https://www.ncc.gov.ir/).

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Fig 2.

Multiple environmental alterations and social activities were major forces for the induction of emergence/re-emergence of anthroponotic cutaneous leishmaniasis repeated outbreak waves in Bam, southeastern Iran.

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Fig 3.

Images of the earthquake destroyed 90% of raw brick-made houses and created a suitable sandfly breeding condition for transmission of anthroponotic cutaneous leishmaniasis in Bam, southeastern Iran (the research team took the above pictures in 2003 following the earthquake of Bam).

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Table 1.

Representing the baseline population of patients with cutaneous leishmaniasis in Bam, southeastern Iran, 1971–2020.

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Table 2.

Representing age groups, genders, the number of lesions, and anatomical location of lesions in cases with anthroponotic cutaneous leishmaniasis in Bam, southeastern Iran.

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Fig 4.

Repeated outbreak waves following the cessation of spraying against malaria, an extensive widening of the city spaces, and an earthquake occurred in Bam, southeastern Iran (1971–2020).

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Fig 5.

Incidence of cutaneous leishmaniasis (CL) cases before and after three major events.

Vertical lines indicate the two years after every event; dotted line indicates the observed incidence of CL; dashed line indicates the trend before every event; solid line indicates the trend after every event in Bam, southeastern Iran (1971–2020).

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Table 3.

Interrupted time series parameters to evaluate trends in incidence per 1,000 of cutaneous leishmaniasis in Bam, southeastern Iran (1971–2020).

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Table 4.

Changes in cutaneous leishmaniasis (CL) incidence per 1,000 after three major events in Bam, southeastern Iran (1971–2020).

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Fig 6.

Illustrating the sequence of emerging foci in order of occurrence in Bam, southeastern Iran (1971–2020).

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