Table 1.
Severity score for acute dog tungiasis (SCADT) used at each clinical exam of dogs in a trial of the efficacy of oral fluralaner for treatment of this parasite.
Table 2.
Distribution of age, weight, sex, flea count and total severity score (SCADT) on Day 0.
Table 3.
Tunga penetrans free dogs at various time points following either a single oral dose of fluralaner or no treatment.
Fig 1.
Front paws of fluralaner treated and untreated dogs.
(A) Treated dog on day 0 showing multiple stage II (example in black arrow) and III (examples in red arrows) T. penetrans lesions. (B) Same dog day 7—no active lesions and visible parasite involution scars (stage V–examples in black arrows). (C) Same dog day 21—paw pad epithelium has regrown and pad is flea free (D) Untreated dog, on day 0 with multiple active flea lesions on the paw pads of the forelimbs (examples in black arrows). (E) Same untreated dog on day 7—numerous flea lesions in stages II (examples in black arrows) and III (examples in red arrows). (F) Same untreated dog—day 21, with flea active lesions II (example in black arrow) and III (example red arrow), indicating reinfestation. Notice that there are more lesions in Fig 1A, 1D, 1E and 1F than the arrows are showing. Source: author’s photographic collection.
Fig 2.
Geometric means of log-transformed live flea counts per study group over time.
Table 4.
Live Tunga penetrans counts (secondary efficacy and p values) on fluralaner treated and untreated dogs at various time points following treatment.
Table 5.
Two-sided t-test for paired observations, estimating the difference of flea counts between day 0 and the time points after treatment for the CG.
Fig 3.
Mean severity score for acute dog tungiasis (SCADT) per study group over time.
Table 6.
Clinical scores as measured by mean SCADT (data by inspection time point by study group and p-values) in fluralaner treated and untreated dogs naturally exposed to Tunga penetrans.
Fig 4.
Continued protection and improvement in paw clinical appearance in a fluralaner treated dog.
(A) Day 0—multiple stage II (examples marked by black arrows) and III (examples marked by red arrows) lesions caused by T. penetrans, located on the paw pads. (B) Day 28—no active sand flea lesions. (C) Day 60—paw pad epithelium regrowth and no new infestations. (D) Day 90 –normal paw pads. Notice that there are more lesions in Fig 4A than the arrows are showing.