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Fig 1.

Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) flow diagram of the study selection process.

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Fig 2.

Geographical distribution of included published articles.

The colour corresponds to the type of article (see key), and the size of the marker corresponds to the number of articles published in that country. There were no more than two articles of the same type from one country. Bubble map created with Plotly Graphing Libraries - Made with Natural Earth. Free vector and raster map data @ naturalearthdata.com.

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Table 1.

Summary of the observational studies.

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Table 2.

Quality Assessment of Observational Studies.

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Table 3.

Quality Assessment of Case Reports and Case Series.

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Table 4.

Characteristics of patients with leptospirosis in pregnancy.

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Table 5.

Clinical characteristics of leptospirosis in pregnancy.

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Table 6.

Summary of diagnostics, differential diagnoses and outcomes reported for cases of leptospirosis in pregnancy.

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Table 7.

Relationship between maternal clinical characteristics and adverse fetal outcomes.

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Table 8.

Antibiotic therapy.

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