Fig 1.
Flowchart showing the number of participants at each stage of data selection, leading to the final analysis set.
Table 1.
Demographic characteristics of participants according to O. viverrini infection and diabetes mellitus status.
The data are presented as frequencies and percentages for the overall sample and separated by O. viverrini infection and diabetes mellitus status.
Fig 2.
Breakdown of study population according to O. viverrini infection and diabetes mellitus status.
Data show percentages of the study population falling into each of the four possible combinations of O. viverrini infection and diabetes mellitus status according to gender and overall.
Fig 3.
Breakdown of study population according to O. viverrini infection and diabetes mellitus status.
Data show percentages of the study population falling into each of the four possible combinations of O. viverrini infection and diabetes mellitus status according to age groups.
Table 2.
Association of O. viverrini infection, diabetes mellitus diagnosis and other factors with cholangiocarcinoma using multilevel mixed-effects logistic regression.
The data are presented as number of participants, number and percentage having cholangiocarcinoma, crude odds ratios with their 95% confidence intervals and p-values from likelihood-ratio chi-square tests, and adjusted odds ratios and their 95% confidence intervals and p-values from likelihood-ratio chi-square tests for each factor.
Fig 4.
Percentages of individuals with cholangiocarcinoma in relation to O. viverrini infection and diabetes mellitus status overall (A) and according to gender (B).
Data show the rate of cholangiocarcinoma as percentage for overall O. viverrini infection and diabetes mellitus groups, and combination of O. viverrini infection and diabetes mellitus separated by sex.
Fig 5.
Numbers of cholangiocarcinoma cases by age and in relation to O. viverrini infection and diabetes mellitus status.
Data shows the number of cholangiocarcinoma cases according to combination of O. viverrini infection and diabetes mellitus according to age in year.
Table 3.
Association of combinations of O. viverrini infection and diabetes mellitus with cholangiocarcinoma using multilevel mixed-effects logistic regression.
The data are presented as numbers of participants, numbers and percentages having cholangiocarcinoma, crude odds ratios and their 95% confidence interval and p-value from likelihood-ratio chi-square tests, and adjusted odds ratios and their 95% confidence interval and p-values from likelihood-ratio chi-square tests for various combinations of O. viverrini infection and diabetes mellitus.
Fig 6.
Adjusted odds ratios for the association of cholangiocarcinoma with O. viverrini infection and diabetes mellitus status.
Data show the magnitude of association of cholangiocarcinoma, comparing groups infected with O. viverrini (OV+), diabetes mellitus (DM+), and combinations of these (OV- & DM+, OV+ & DM- and OV+ & DM+). In each case, the comparison is against the group without diabetes mellitus or O. viverrini infection.