Fig 1.
The data from the 15 studies, with 2,270 patients, included in the systematic review are summarized in Table 1. These studies report data from Thailand (n = 4), India (3), Sri Lanka (3), Brazil (2), Nepal (2) and Papua New Guinea (1), on a variety of different snake genera: Daboia (n = 7), Trimeresurus (5), Hypnale (3), Echis (2), Bothrops (2), Calloselasma (1), Ovophis (1), Bungarus (1) and Oxyuranus (1). In several studies, snake genus and species was unknown.
Table 1.
Studies included in the systematic review.
Table 2.
QUADAS-2 Assessment of bias.
Fig 2.
Forrest plot of 20WBCT sensitivity and specificity at detecting coagulopathy, Forrest plot of 20WBCT sensitivity and specificity at detecting coagulopathy defined as INR>1·4.
Studies displayed individually and pooled. Circle size is proportional to sample size, whiskers represent 95% confidence interval.
Fig 3.
SROC curve for 20WBCT at detecting coagulopathy.
SROC curves for 20WBCT at detecting mild coagulopathy defined as INR>1·4.
Fig 4.
Forrest plot of 20WBCT sensitivity and specificity at detecting coagulopathy defined as fibrinogen < 100mg/dL.
Studies displayed individually and pooled. Circle size is proportional to sample size, whiskers represent 95% confidence interval.
Fig 5.
SROC curve for 20WBCT at detecting coagulopathy.
SROC curves for 20WBCT at detecting mild coagulopathy defined as fibrinogen <100 mg/dL.
Fig 6.
A density plot displaying the distribution of false negative and true positive 20WBCT results using a reference test of INR.
Fig 7.
A density plot displaying the distribution of false negative and true positive 20WBCT results using a reference test of fibrinogen.
Fig 8.
SROC curve for 20WBCT at detecting coagulopathy.
SROC curves for 20WBCT at detecting severe coagulopathy defined as INR>5 or fibrinogen <50 mg/dL.
Table 3.
Summary of studies performing 20WBCT after antivenom.