Table 1.
Summary of study tests.
Table 2.
Characteristics of the study population.
Fig 1.
Histogram showing the distribution of G6PD activities in the study population.
The frequency is plotted against the normalized reference assay G6PD activity in 10% increments for A) males, and B) females. The 30%, 70%, and 80% activity limits are indicated on each plot. G6PD, glucose-6-phosphate dehydrogenase.
Table 3.
Number of females and males within intermediate G6PD activity ranges (50 to 80%).
The fluorescent spot test (FST) results that are available are also shown. The results are provided in terms of normal, intermediate, and deficient (N:I:D).
Fig 2.
ROC curves at 30% and 70% G6PD activity thresholds on A) venous specimens and B) capillary specimens. ROC, receiver operating curve.
Table 4.
Diagnostic performance of the STANDARD G6PD Test using the manufacturer’s thresholds compared with normalized spectrophotometric reference values, by specimen type.
Table 5.
Diagnostic performance of the 6.0 U/g Hb threshold on the STANDARD G6PD Test for all females on capillary specimens (n = 922).
The sensitivity, specificity, and predictive power for all females with less than 70%, 65%, and 60% activity are shown.
Table 6.
Percent agreement between the STANDARD G6PD Test and the spectrophotometric reference test using the manufacturer’s threshold values at 30% and 70% G6PD activity thresholds, on venous specimens.
Table 7.
Percent agreement between the STANDARD G6PD Test and the spectrophotometric reference test using the manufacturer’s threshold values at 30% and 70% G6PD activity thresholds, on capillary specimens.
Fig 3.
Regression analysis of STANDARD G6PD Test’s G6PD activity on A) venous specimens and B) capillary specimens, compared to normalized spectrophotometric reference test on venous specimens.
Fig 4.
Regression analysis of STANDARD G6PD Test total hemoglobin measurement on A) capillary specimens compared to complete blood count, B) venous specimens compared to complete blood count (Manaus only). CBC, complete blood count; Hb, hemoglobin.