Fig 1.
Survey process and sample analysis.
Table 1.
Survey sample demographics and screening findings.
Fig 2.
G6PD activity distribution and malaria microscopy positivity in the survey.
Fig 3.
Genotypes identified among the subjects having <80% of normal G6PD activity and that phenotype illustrated in relation to 30% and 70% of normal activity thresholds.
CO, VC, and VL Hom are Coimbra, Viangchan, and Vanua Lava homozygous respectively. CO, VC, CT and VL Het are Coimbra, Viangchan, Chatham and Vanua Lava heterozygous respectively. VL & CT and VL & VC represent the 3 compound heterozygotes of those variants. The ND lane represent subjects negative for the G6PD variant SNPs analyzed, but not whole gene sequenced, whereas the Normal lane represents those whole gene sequenced as wild type G6PD. The black dots represent outliers calculated from the boxplot whereas the pink outliers are calculated from the scatterplot of same samples.
Fig 4.
Distribution of G6PD genotypes among phenotypic activity thresholds.
ND-not determined, CO–Coimbra, VC–Viangchan, VL–Vanua Lava, CT–Chatham, and KP–Kaiping. Hom–homozygous mutant and Het–heterozygous. VL & CT, and VL & VC represent the compound heterozygotes.
Table 2.
Summary of diagnostic performance of the CSG specific to genotypes and G6PD activity ranges among individual subjects below 80% of normal.