Table 1.
Diagnostic grading system to judge the certainty of the correct diagnosis of LBRF.
Fig 1.
Flow diagram of search and selection of eligible publications.
Table 2.
Details of all identified studies that included untreated cases, in chronological order and according to diagnostic grading.
Table 3.
Numbers of diagnosed cases and respective CFR.
Fig 2.
CFR of LBRF cases from the reviewed studies according to treatment modality over time.
The dots correspond to the CFR of the respective group. The columns represent the absolute number of cases. The table gives detailed information on the data for each segment of time. Note: Since the data set is compiled from published literature reporting on cases, outbreaks and clinical studies from different regions, different populations as well as different seasons, no trend in annual incidence of LBRF can be inferred.
Fig 3.
CFR in relation to treatment modality, time, and geographical region.
Table 4.
Risk factors, symptoms, and signs for mortality and poor prognosis reported in literature.
Table 5.
Details of all the included studies that published data on the JHR, in chronological order and according to diagnostic grading.
Table 6.
Details of all the studies including data on LBRF infection during pregnancy, in chronological order and according to grade of diagnostic certainty.
Fig 4.
Adverse pregnancy outcomes in LBRF cases.
(A) Microscopically diagnosed cases. (B) Microscopically and clinically diagnosed cases. One study reported adverse pregnancy outcomes without specifying them (gray color) [89].