Table 1.
Demographic, clinical and biological characteristics of included patients at hospital admission (n = 243).
Table 2.
Demographic (gender and age), dengue immune status, laboratory-confirmed dengue diagnosis and hospitalization duration of acute dengue-infected children included in the study in terms of the WHO 1997 and adapted WHO 2009 dengue classifications (n = 173).
Table 3.
Comparison of WHO 1997 and adapted WHO 2009 dengue classifications among hospitalized children with laboratory-confirmed dengue diagnoses (n = 173).
Table 4.
Description of hemorrhagic and shock clinical manifestations presented by laboratory-confirmed dengue patients classified as DF (n = 78) using the WHO 1997 case definition, with comparison to the adapted WHO 2009 dengue classification.
Table 5.
Distribution of dengue patients in the critical phase at Visit 3 with follow-up, with respect to their WHO 1997 and adapted WHO 2009 dengue classifications.
Table 6.
Description of biological and clinical manifestations presented by laboratory-confirmed dengue patients classified as SD (n = 52) adapted from the WHO 2009 case definition.
Fig 1.
Dengue viral load at admission and NS1 antigen levels during hospitalization in dengue-infected patients using the adapted WHO 2009 classification scheme.
Dengue with warning signs (DWWS; green circles), severe dengue (SD; pink squares). Error bars correspond to the 95% confidence interval around the mean.
Fig 2.
Hematological parameters observed in hospitalized dengue-infected patients for the adapted WHO 2009 classification scheme.
Values from admission, deferverscence, and discharge visits for: dengue with warning signs (DWWS; green circles), severe dengue (SD; pink squares). (A) Leucocytes count (109/L); (B) Lymphocytes count (109/L); (C) Neutrophils count (109/L); (D) Hematocrit rate (%); (E) Platelet count (109/L). Each circle or square represents the mean of each variable's observed values per day. Error bars correspond to 95% confidence intervals around the mean. Grey areas represent the normal range for each parameter. Normal ranges used for hematological parameters were obtained for children aged from 2 to 15 years old from: http://www.hematocell.fr/index.php/les-cellules-du-sang/15-les-cellules-du-sang-et-de-la-moelle-osseuse/valeurs-normales-de-lhemogramme-selon-lage/129-hemogramme-selon-lage.
Fig 3.
Biochemical parameters observed in hospitalized dengue-infected patients using the adapted WHO 2009 classification scheme.
Values at admission, deferverscence and discharge for: dengue with warning signs (DWWS; green circles), severe dengue (SD; pink squares). Liver function: (A) Alanine aminotransferase (ALT; IU/L); (B) Aspartate aminotransferase (AST; IU/L); Lipid profile: (C) Total cholesterol (mmol/L); (D) HDL cholesterol (mmol/L); (E) Calculated LDL cholesterol (mmol/L); (F) Triglycerides (mmol/L). Each circle or square represents the mean of each variable's observed values per day. Error bars correspond to 95% confidence intervals around the mean. Grey areas represent the normal range for each parameter. Normal ranges used for biochemical parameters were obtained from: https://emedicine.medscape.com/article/2172316-overview.