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Table 1.

Characteristics of the studies selected and test properties calculated after creating a 2 x 2 table.

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Fig 1.

Flow chart of included studies.

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Fig 2.

QUADAS-2 results showing risk of bias and applicability concerns of the studies selected.

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Fig 3.

Couplet forest plots of the studies selected in Review Manager 5.3.

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Fig 4.

HSROC curve for PCR.

A. In smear sample, reference standard A, case control and consecutive studies combined. Circles represent estimates of individual primary studies, and square indicates summary points of sensitivity and specificity. The circled region around the solid square represent the 95% CI region around the summary estimate. HSROC curve is obtained using command “metandiplot” in STATA version 14. B. In skin biopsies and aspirate samples, reference standard B and case control and consecutive studies combined. Circles represent estimates of individual primary studies, and square indicates summary points of sensitivity and specificity. The circled region around the solid square represent the 95% CI region around the summary estimate. HSROC curve is obtained using command “metandiplot” in STATA version 14.

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Table 2.

Summary estimates for PCRa.

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