Fig 1.
Patient flow chart and classification of patients.
Table 1.
Baseline characteristics of cases with a proven infectious etiology.
Fig 2.
The number or percentage of activated neutrophils (Neut-RI), lymphocytes (Re-Lymph and AS-Lymph), and monocytes (Re-Mono) in patients with a proven infection.
The lines indicate median with interquartile ranges. Differences were analyzed using Kruskal Wallis test with post-hoc tests. The lines indicate a statistically significant difference (P<0.05) considering correction of the P value for multiple testing (Benjamini-Hochberg). WBC, white blood cells.
Fig 3.
The absolute number or percentage of activated neutrophils (Neut-RI), lymphocytes (Re-Lymph and AS-Lymph) and monocytes (Re-Mono) in patients with proven or proven/probable infections, aggregated in bacterial or arboviral infections.
The lines indicate median with interquartile ranges. Differences were analyzed using Kruskal Wallis test with post-hoc tests. WBC, white blood cells.
Table 2.
IMS Classification in proven cases and in combined proven/probable cases.
Fig 4.
C-reactive protein (CRP) and procalcitonin (PCT) concentrations.
(A) enrolled patients with a proven infection aggregated per infection; (B) enrolled patients with a proven or probable infection aggregated in bacterial or arboviral infections. The lines with error bars indicate median with interquartile range. Differences were analyzed using Kruskal Wallis test with post-hoc tests with multiple testing correction (Benjamini-Hochberg). * indicates P<0.05.
Table 3.
Diagnostic performance of the IMS compared with CRP and PCT.