Table 1.
Patient characteristics.
Fig 1.
Principal component analysis of 1H-NMR CSF metabolomic data comparing infectious or autoimmune disease or controls.
Axes represent principal component (PC) scores. The percent of the variation explained by each component is given in parentheses. Green circles represent control patient samples, red circles represent multiple sclerosis patient samples, and blue circles represent infectious disease patient samples. Normal data ellipses are shown for each group. Vectors represent loadings of select metabolites with PC1 and PC2, as drawn in the Gabriel’s biplot. Groups of vectors that point in similar directions tend to change together. One extreme observation was excluded to better visualize the data.
Table 2.
Differences in cerebrospinal fluid metabolite concentrations between patients with an infectious disease (Hisotoplasma, Lyme, rabies, West Nile virus) and non-infectious conditions (multiple sclerosis, controls)a.
Fig 2.
Principal component analysis of 1H-NMR CSF metabolomic data comparing neurological diseases.
Samples were collected from patients with multiple sclerosis (MS, represented in green), fungal infection (red), Lyme disease (blue), West Nile virus (WNV, orange), and rabies (purple). Normal data ellipses are shown for each group. Axes represent principal component (PC) scores. The percent of the variation explained by each component is given in parentheses. Vectors represent loadings of select metabolites with PC1 and PC2, as drawn in the Gabriel’s biplot. Groups of vectors that point in similar directions tend to change together. One extreme observation was excluded.
Table 3.
Metabolites with differences in cerebrospinal fluid concentrations between two or more disease groupsa.
Table 4.
Differences in cerebrospinal fluid metabolite concentrations compared to controls, by disease.
Table 5.
Predictive analyses using classification and regression trees (CART) and random forest importance scores.