Table 1.
Clinical characteristics of Chagas’ megaesophagus.
Fig 1.
Six studies evaluated isosorbide, one evaluated nifedipine, and one evaluated both. Four studies had a before-after design, and four were crossover trials.
Table 2.
Characteristics of studies included in the systematic review.
Fig 2.
Effect of isosorbide on lower esophageal sphincter pressure 10 minutes after administration.
Fig 3.
Effect of isosorbide on esophageal retention 5 minutes after meal ingestion.
Esophageal retention is an indicator of esophageal emptying.