Fig 1.
Deaths include Chagas related mortality in the acute and chronic states. Identification and treatment for states varies by scenario.
Table 1.
Model input parameters, values, and sources.
Fig 2.
Number of new acute cases over time when identifying and treating different percentages of Chagas patients annually in the A) acute stage, and B) the indeterminate stage.
Table 2.
Cumulative number of acute Chagas cases identified and completing treatment and the impact of treating in Chagas disease in the acute stage on the number of chronic cases and median cost (95% uncertainty interval) over time when identifying and treating different percentages of patients annually.
Fig 3.
Incremental cost and effectiveness of compared to no earlier treatment from the third-party payer and societal perspectives when identifying and treating an increasing proportion of Chagas patients in A) the acute stage, B) the indeterminate stage, and C) the acute and indeterminate stages. Costs and disability-adjusted life years (DALYs) are in net present value (2018 $US).
Fig 4.
Cost-benefit (net present value, 2018 $US) over time of when identifying and treating different percentages of Chagas patients in the acute or indeterminate stage annually compared to no treatment from the societal perspective when treatment cost A) $50 per person, B) $100 per person, and C) $300 per person.
Table 3.
Cumulative number of indeterminate Chagas cases identified and completing treatment and the impact of treating in Chagas disease in the indeterminate stage on the number of chronic cases and median cost (95% uncertainty interval) over time when identifying and treating different percentages of patients annually.
Table 4.
Cumulative number of acute and indeterminate Chagas cases identified and completing treatment and the impact of treating in Chagas disease in the acute and indeterminate stages on the number of chronic cases and median cost (95% uncertainty interval) over time when identifying and treating different percentages of patients annually.