Fig 1.
Study participants.
Fig 2.
(A) Hypothesized pathways for developing dengue, DHF, or DSS and structural equation models predicting (B) dengue, (C) DHF, and (D) DSS. (B) The model fits were RMSEA = 0.057 and CFI = 0.979. (C) The model fits were RMSEA = 0.000 and CFI = 1.000. (D) The model fits were RMSEA = 0.095 and CFI = 0.937. Arrows indicate hypothetically significant positive or negative associations in (A). Solid and dotted arrows indicate significant positive and negative associations, respectively, in (B), (C), and (D). Unstandardized (= B) and standardized (= β) coefficients are shown next to the arrows. Correlations were omitted from the diagram. Unit: age, y; AST, U/mL; ALT, U/mL; WBC, cells/mm3; Lymphocytes, %; Albumin, g/dL; Hematocrit, %; Platelets, cells/mm3; Tourniquet test, petechiae/in2. AST, ALT, WBC, hematocrit, platelets, and tourniquet test were ln-transformed. Thickness of arrows was determined by standardized coefficients. *P value <0.05, **P value <0.01, ***P value <0.001.
Table 1.
Characteristics of study participants (n = 257).
Table 2.
Total effect of predictors at fever day -3 in developing dengue, DHF, and DSS based on SEMs.
Fig 3.
ROC curves for external validation employing fever days: (A) dengue, (B) DHF, and (C) DSS. n = 878 (nfever day -3 = 143, nfever day -2 = 366, nfever day -1 = 590, and nfever day 0 = 617).
Fig 4.
ROC curves for external validation employing study days: (A) dengue, (B) DHF, and (C) DSS. n = 896 (nstudy day 1 = 880, nstudy day 2 = 579, and nstudy day 3 = 318).
Fig 5.
ROC curves for external validation employing illness days: (A) dengue, (B) DHF, and (C) DSS. n = 885 (nillness day 2 = 267, nillness day 3 = 481, nillness day 4 = 572, and nillness day 5 = 377).