Fig 1.
Scheme showing the bioassay guided fractionation of the methylene chloride extract of Lantana camara leaves (LCL mc) and the structure of lantadene A contained in fraction C+D-D4.
Fig 2.
Graphical representation of IC50 and IC100 of active extracts against microfilariae of L. loa compared to the values for O. ochengi.
(TILmc: methylene chloride extract from Tamarindus indica leaves; LCLhex: hexane extract from Lantana camara leaves; LCLmc: methylene chloride extract from Lantana camara leaves).
Table 1.
Percentage yields and IC50s of the extracts in secondary screens for the male, female and microfilariae (mf) of Onchocerca ochengi and the mf of Loa loa.
Table 2.
Comparison of the effect of different extracts and concentrations on the mean activity of O. ochengi females.
Table 3.
Comparison of the effect of different extracts and concentrations on the mean activity of O. ochengi males.
Table 4.
Comparison of the effect of different extracts and concentrations on the mean activity of O. ochengi microfilariae.
Table 5.
Comparison of the effect of different extracts and concentrations on the mean activity of Loa loa microfilariae.
Table 6.
Cytotoxic concentrations (CC50) and selectivity indices (SI) of the extracts on the parasites.
Table 7.
Phytochemical analysis for TILmc, LCLhex, and LCLmc extracts.
Table 8.
Activities of fractions and sub-fractions from LCLhex, LCLmc and TILmc extracts and lantadene A against O. ochengi adult worms and larvae.
Fig 3.
Dose dependent relationships of lantadene A to parasite viability: A) % inhibition of motility of O. ochengi male worms. B) % inhibition of formazan by O. ochengi females. C) % inhibition of motility of Loa loa microfilariae (mf). D) % inhibition of motility of O. ochengi mf.