Fig 1.
Group A1, participants receiving PCECV according to the 4-site/1-week ID regimen; Group A2, participants receiving PCECV according to the 4-site/1-week ID regimen and HRIG at first visit; Group B1, participants receiving PCECV according to the 2-site/TRC regimen; Group B2, participants receiving PCECV according to the 2-site/TRC regimen and HRIG at first visit; PCECV, purified chick embryo cell culture vaccine; ID, intradermal; HRIG, human rabies immunoglobulin; TRC, Thai Red Cross; n, number of participants in each age stratum; N, number of participants in each group; PPS, per-protocol set. * One 11-year-old participant was erroneously randomized in Group B2. ** Not due to an adverse event.
Fig 2.
Group A1, participants receiving PCECV according to the 4-site/1-week ID regimen; Group A2, participants receiving PCECV according to the 4-site/1-week ID regimen and HRIG at first visit; Group B1, participants receiving PCECV according to the 2-site/TRC ID regimen; Group B2, participants receiving PCECV according to the 2-site/TRC ID regimen and HRIG at first visit; PCECV, purified chick embryo cell culture vaccine; ID, intradermal; HRIG, human rabies immunoglobulin; TRC, Thai Red Cross; D, day; BD, blood draw. Administration schemes represent injection sites. The syringe symbolizes 1 injection of 0.1 mL of PCECV vaccine.
Table 1.
Demographics characteristics of participants at enrolment.
Table 2.
Summary of between-groups comparison of immune response to different PCECV regimens in terms of percentage of participants with RVNA concentrations ≥0.5 IU/mL and GMCs (per-protocol set at each time point).
Table 3.
Number and percentages of participants with solicited adverse events after any vaccination, and unsolicited and serious adverse events throughout the study (safety set).