Fig 1.
Summary of the factors that influence TF and DR in Leishmania.
ABC, ATP-binding cassette; AQP, aquaporin; DR, drug resistance; LRV, Leishmania RNA virus; TF, treatment failure.
Fig 2.
Molecular mechanisms of antimonial DR in Leishmania.
The figure illustrates an amastigote inside a phagolysosome of the macrophage host cell. It explains the activation and influx methods used by antimonials to enter the parasite and the intracellular mechanisms used by the parasite to express the resistant phenotype. ABC, ATP-binding cassette; AQP, aquaporin; DR, drug resistance; IL-10, interleukin 10; MDR1, multidrug resistance protein 1.