Table 1.
Characteristic of andes virus-infected patients (n = 43).
Table 2.
Available clinical and laboratory findings at the time of sample collection.
Fig 1.
IL-1β, IL-12p70, and IL-21 levels in control and ANDV-infected patients.
Circulating levels of cytokines (A) IL-1β, (B) IL-12p70 and (C) IL-21 in serum samples of Control individuals and ANDV-infected patients with Mild or Severe disease progression are represented by dots. IL-1β and IL-12p70 were expressed in pg/mL while the circulating levels of IL-21 are expressed as Log10 (pg/mL) to facilitate comparison between the groups. A Mann-Whitney test for continuous variables was performed to evaluate significant differences between Controls and Mild or Severe, and Severe versus Mild groups. The ends of the brackets indicate the compared groups. The dashed line represents the lower limit of detection. Each serum sample was analyzed in duplicate in the same plate.
Fig 2.
TNF-α, IFN-γ, IL-10, and IL-6 levels in control and ANDV-infected patients.
Circulating levels of cytokines (A) TNF-α, (B) IFN-γ, (C) IL-10, and (D) IL-6 in serum samples of Control individuals and ANDV-infected patients with Mild or Severe disease progression are represented by dots. Each value expressed in pg/mL was transformed to Log10 (pg/mL) to facilitate comparison between the groups. A Mann-Whitney test for continuous variables was performed to evaluate significant differences between Controls and Mild or Severe, and Severe versus Mild groups. The dashed line represents the lower limit of detection. The ends of the brackets indicate the compared groups. Each serum sample was analyzed in duplicate in the same plate.
Fig 3.
Serum levels of IL-6 in control, HCPS survivals or fatal cases.
Circulating levels of IL-6 in serum samples of control individuals and HCPS survivors or fatalities are represented by dots. Values are expressed in Log10 (pg/mL). A Mann-Whitney test for continuous variables was performed to evaluate significant differences between controls individuals and HCPS survivors or fatalities. The ends of the brackets indicate the compared groups. The dashed line represents the lower limit of detection. Each serum sample was analyzed in duplicate in the same plate.
Table 3.
Cytokine concentration in serum of controls and ANDV-infected patients.
Table 4.
Cytokine concentration in serum of survivors or deceased ANDV-infected patients.
Table 5.
Logistic regression of clinical and cytokine level variables.