Fig 1.
Schematic of the transmission cycle of Lassa virus in Mastomys natalensis and in humans.
Table 1.
Value of the parameters used in the numerics.
See List of Symbols and Glossary in the Supporting Information, S1 Text, for further details.
Fig 2.
(a) Cumulative number of zoonotic infections generated by the ABM (10 independent runs, grey points) for the case when the rate of infection is not affected by the number of humans already infected (no human-to-human transmission) or by depletion of susceptibles (’Simple Poisson’ model). According to model (1) the mean cumulative number of zoonotic infections grows linearly with λ (green line). (b) Quantile-Quantile plot of the distribution of infections, generated by the ABM compared with the theoretical Poisson distribution. (c) As in panel a, but the rate of infection is also subjected to random variation (‘Poisson-Gamma-Mixture’ model); the green line represents the mean cumulative number of zoonotic infections as in panel a. (d) Quantile-Quantile plot of the distribution of infections generated by the ABM compared with the theoretical negative binomial distribution.
Fig 3.
(a) Cumulative number of infections generated by the ABM (10 independent runs, grey points) for zoonotic spillover with depletion of susceptbibles model (‘Self-Correcting Poisson’); its analytical solution (green line), is given by Eq (S3) in S7 Text. (b) Cumulative number of infections arising from human-to-human transmission generated by the ABM (10 independent runs, grey points) and no depletion of susceptibles (‘Poisson with Feedback’ model). In the special case of no mortality and no recovery, its analytical solution (green line), is an exponential function (Eq (S10) in S7 Text). (c) Cumulative number of infections generated by the ABM (10 independent runs, grey points) for zoonotic spillover with human-to-human transmission and depletion of susceptibles (‘Poisson with Feedback’ model). The dashed blue line represents the mean cumulative number of infections; the special case of no mortality and no recovery is represented by the green line (Eq (S10) in S7 Text).
Fig 4.
Estimating the relative contributions of zoonotic spillover and human-to-human transmission.
Comparison with ABM III.(a) Cumulative number of infections for zoonotic spillover with human-to-human transmission and depletion of susceptibles (‘Poisson with Feedback’ model) generated by the ABM (10 independent runs). The green and red points represent cumulative infections arising from zoonotic and human-to-human transmission respectively. The continuous blue and black line represent the analytical solutions and the isolated contributions of zoonotic, , and human-to-human transmission,
, recalculated with parameters (median values of ζ and κ, right panel) estimated from the MCMC. (b) Traceplot of the time series and histogram of the two parameters: ζ (median 0.008338, mean 0.008364, SE 0.0006919, bandwidth 0.0001162) and κ (median 0.055118, mean 0.055134, SE 0.0033703, bandwidth 0.0005541) number of iterations 10000, burning time 1000, thinning interval 1. The small discrepancy between the parameters and the ones imposed in the ABM (respectively 0.05 and 0.01) is expected as the ABM simulates Bernoulli trials rather than Poisson processes. Full agreement is expected when the number of trials approaches infinity.
Fig 5.
(a) Predicted cumulative number of zoonotic and human-to-human infections (governed by ‘Poisson with Feedback’ model, Eq (12)) for constant zoonotic exposure and (b) As in (a), but exposure to zoonotic LASV is governed by an piecewise linear trend in exposure to zoonotic LASV (i.e. the piecewise zoonotic exposure ζ is linearly increasing up to March 2011 followed by a decrease up to January 2012). The parameters are optimized with the data from KGH (red line) by employing MCMC (number of iterations 50000, burning time 1000, thinning interval 1). The grey dots represent 100 independent stochastic realisations; 5 five random examples of which are visualized in blue lines. The black line represents the cumulative number of occurrences averaged over the 100 multiple stochastic realisations.