Fig 1.
Chemical structures of PZQ, the main metabolite trans-4-OH and PZQ-d11 (internal standard), with the chiral centre represented with a shaded circle.
Table 1.
Characteristics of participants and O. viverrini cure rates.
Fig 2.
Plasma concentrations for R-PZQ (1), S-PZQ (2) and R-trans-4-OH (3) over time and across patients (patient 2 sketched with a star) and analyte concentrations across the 3 matrices in patient 1.
Table 2.
Median (range) of AUC0–24h, t1/2, Cmax and Tmax in plasma across 9 patients.
Table 3.
Concordance of blood and DBS compared to plasma measurements, evaluated with Pearson’s correlation and percentage ratio with their 95% limits of agreement (LoA).
Fig 3.
Bland-Altman plots of measurement performed with blood or DBS compared to plasma values for R-PZQ, S-PZQ and R-trans-4-OH with mean ratio sketched with a solid line and 95% limits of agreement with dashed lines.
Fig 4.
Bland-Altman plots of AUC values obtained from blood or DBS compared to plasma AUCs for R-PZQ, S-PZQ and R-trans-4-OH with mean ratio sketched with a solid line and 95% limits of agreement with dashed lines.
Patient 2 is depicted with a triangle (▲).
Table 4.
Mean percentage ratios of AUC0–24h values in blood or DBS compared to plasma and lower and upper 95% limits of agreement (LoA) with their respective 95% confidence intervals (CI).
Table 5.
Percentage ratios of t1/2, Cmax and Tmax in blood or DBS compared to plasma.