Table 1.
Clusters indicated as mapping priorities with their constituent diseases recommended for distribution modelling and current global mapping projects identified.
Fig 1.
Hierarchical organisation of the 33 clusters.
The 176 diseases with strong rationale for mapping were first sorted by taxonomy of pathogenic agent (in orange) and then structured by common epidemiological and transmission characteristics into sub-groupings (in blue) and finally clusters (in red). STH = soil transmitted helminth, VBD = vector borne disease.
Fig 2.
Plot showing the 33 clusters of diseases as ranked by burden of disease DALYs (y-axis—logarithmic scale) and mean policy priority score of occurrence mapping and prevalence mapping diseases (x-axis—linear scale). The top ten clusters circled and numbered as identified in Table 1. The size of the circle is determined by the total number of diseases contained and colour is based upon taxonomy (as outlined by Fig 1; the web appendix contains the full disease listing for each cluster). The dashed guidelines are perpendicular to the axis along which prioritisation order for the clusters was determined; those closer to the top right, along this axis, were prioritised higher.
Fig 3.
A “species accumulation” curve showing the cumulative number of diseases of interest sampled by increasing numbers of public health stakeholders examined.
The diseases of interest of twenty global health stakeholders was indexed and plotted (see Methods). As additional organisations are sampled beyond the fifteen used in this study, the number of unique diseases identified plateaus at around 42. Thus not all public health stakeholders need to be sampled to capture the global diversity of diseases of public health interest.
Fig 4.
Cumulative percentage barplot indicating the cumulative percentage of DALYs accounted for by each cluster.
The colouring is based upon taxonomy, as in Fig 2. The red line indicates the top ten clusters, the dark green indicates the top 15.
Fig 5.
Plots indicating the relative importance of each mapping cluster.
(A) Area of each section is determined by the total DALY contribution of each of the 33 clusters. Blue indicates a cluster contributing to the top ten clusters to be prioritised, green indicates top 44 diseases (n = 5 clusters) and light green represents the remaining disease clusters (n = 18). (B) Area of each section is determined by the total DALY contribution of 30 clusters, with HIV, tuberculosis and malaria excluded. Blue indicates a cluster contributing to the top ten clusters to be prioritised (n = 7), green indicates top 44 diseases (n = 5 clusters) and light green represents the remaining disease clusters (n = 18). STH = soil-transmitted helminth, (B)—bacteria, (N)—nematode, (Pl)—platyhelminth, (V)—virus. (C) Area of each section is determined by the total policy interest score of each of the 33 clusters. Red indicates a cluster within the top ten to be prioritised, orange indicates one of top 44 diseases (n = 5) and light pink represents the remaining disease clusters (n = 18). STH = soil-transmitted helminth, (B)—bacteria, (N)—nematode, (Pl)—platyhelminth, (V)—virus.