Fig 1.
A) Schematic work flow of the study in western Sumba in 2012 and B) map of G6PD deficiency and malaria prevalences in study sites in Sumba.
Small inlet showed the map of Indonesia and where Sumba island is located.
Table 1.
Demographic, malaria and G6PDd prevalence data by gender and ecosystem in western Sumba.
Fig 2.
G6PD activity distribution curves in both males (blue) and females (red) in 2 different ecosystems.
Black line in both graphs represents the 4.6 U/g Hb as cut off from the Trinity quantitative test manual. A) represents coastal and B) inland areas of western Sumba.
Table 2.
G6PD activities in normal and deficient subjects by gender in western Sumba.
Fig 3.
Scatter plot of G6PD activities of G6PD deficient and normal subjects from Trinity quantitative versus kinetics assays measured in U/g Hb.
The different colours represented different variant (V in either normal, heterozygous and hemizygous mutants. VL Het, VC Het and CT Het represented heterozygous females having Vanua Lava, Viangchan and Chatham variant respectively. VL Hem, VC Hem and CT Hem represented hemizyogous males having Vanua Lava, Viangchan and Chatham variant respectively.
Fig 4.
Impact of Hb level on G6PD activities.
Blue line represents those samples having extremely high G6PD activity and some degree of anemia (R2 = 0.08) and red line represents those having normal Hb level (R2 = 0.48) and t-value = 28.6 (p<0.001).
Fig 5.
Scatter plot showing the relationship between age and G6PD activity in Sumba.
Table 3.
Enzymatic parameters from purified G6PD from study subjects in western Sumba according to genotype.