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Fig 1.

Locations of study areas in Shanxi, China.

A, B, C, D: Datong, Taiyuan, Changzhi and Yuncheng, respectively.

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Fig 1 Expand

Fig 2.

Notified weekly cases of hand-foot-mouth disease (HFMD) and autocorrelation function (ACF) and Partial ACF (PACF) plot of original number of HFMD cases in 4 cities, Shanxi, 2009–2013.

A and E: the number of HFMD cases, ACF and PACF plots of Datong. B and F: the number of HFMD cases, ACF and PACF plots of Taiyuan. C and G: the number of HFMD cases, ACF and PACF plots of Changzhi. D and H: the number of HFMD cases, ACF and PACF plots of Yuncheng.

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Fig 2 Expand

Fig 3.

ACF and PACF plots of integrated the number of HFMD cases.

A, B, C and D show ACF and PACF plots for Datong, Taiyuan, Changzhi and Yuncheng.

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Fig 3 Expand

Table 1.

Meteorological variables and number of HFMD cases in 4 cities, Shanxi, 2009–2013.

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Table 1 Expand

Table 2.

Spearman rank correlations and partial correlations between weekly meteorological variables and HFMD.

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Table 2 Expand

Table 3.

Characteristics of SARIMA models for HFMD in four cities.

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Table 3 Expand

Fig 4.

ACF and PACF plots of residuals after applying the appropriate SARIMA model.

A: ACF and PACF plot of residuals of SARIMA (0,1,1)(2,0,1)52 model for Datong. B: ACF and PACF plot of residuals of SARIMA (2,1,3)(1,1,1)52 model for Taiyuan. C: ACF and PACF plot of residuals of SARIMA (0,1,1)(0,1,1)52 model for Changzhi. D: ACF and PACF plot of residuals of SARIMA (0,1,1)(1,1,2)52 model for Yuncheng.

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Fig 4 Expand

Table 4.

Characteristics of SARIMA models with climate variables for HFMD in four cities.

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Table 4 Expand

Fig 5.

Prediction of the number of HFMD cases on the basis of the model without and with weather variables.

A, B, C, D: Datong, Taiyuan, Changzhi and Yuncheng, respectively.

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Fig 5 Expand

Fig 6.

Dose-response curves of temperature with HFMD occurrence in 4 cities along lags.

The Y axes represent the relative risk (RR) for HFMD within a certain range of temperatures; the grey-shaded areas are 95% CIs. A, B, C, D: Datong, Taiyuan, Changzhi and Yuncheng, respectively.

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Fig 6 Expand