Figure 1.
Pre-exposure neutralizing antibody titers (NTs) in dengue virus serotype 1 (DENV-1) “susceptible” and “non-susceptible subjects.
Graphs show: (a) six DENV-1 PCR positive (“susceptible”) subjects; (b) 13 DENV-1 PCR negative (“non-susceptible”) subjects. NTs for each subject are against the reference strains for DENV-1, -2, -3, -4 and Japanese encephalitis virus (JEV) (red, blue, green, purple and orange, respectively).
Figure 2.
Pre-exposure neutralizing antibody titers (NTs) in dengue virus serotype 4 (DENV-4) “susceptible” and “non-susceptible” subjects.
Graphs show: (a) six DENV-4 PCR positive (“susceptible”) subjects; (b) nine DENV-4 PCR negative (“non-susceptible”) subjects. NTs for each subject are against the reference strains for DENV-1, -2, -3, -4 and Japanese encephalitis virus (JEV) (red, blue, green, purple and orange, respectively).
Figure 3.
Pre-exposure neutralizing antibody titers (NTs) in dengue virus serotype 2 (DENV-2) “susceptible” and “non-susceptible” subjects.
Each row shows one PCR positive (“susceptible”) subject and two matched PCR negative (“non-susceptible”) subjects. NTs for each subject are against (in order from left to right for each subject) the reference strains for DENV-1, -2, -3, -4 and Japanese encephalitis virus (JEV), and six different DENV-2 strains (Asian-American 1982 [#D82-165], Asian I 1974 [#D74-066], Asian I 1984 [#D84-501], Asian I 1994 [#D94-035], Asian I 2004 [#KDS00305]), and homologous DENV-2 Asian I strains).
Table 1.
Characteristics of dengue PCR positive (“susceptible”) and negative (“non-susceptible”) subjects.
Figure 4.
Receiver operating characteristic (ROC) curves for homotypic neutralizing antibody titers (NTs) against reference strains.
Curves discriminate between dengue virus (DENV) PCR positive and negative subjects for: (a) all serotypes combined; (b) DENV-1; (c) DENV-4; (d) DENV-2.
Table 2.
Logistic regression analysis of the relationship between homotypic neutralizing antibody titers and dengue PCR status.a
Table 3.
Comparison of logistic regression models of neutralizing antibody titers to predict dengue PCR status.
Table 4.
Contingency tables showing relationship between homotypic neutralizing antibody titer cutoff values and dengue PCR status.